NCT06167642Enrolling by invitation
Retinal Atrophy and Neurofilament Light Chain in People With Multiple Sclerosis Taking Ofatumumab
Assessing the Modulation of Retinal Atrophy and Neurofilament Light Chain by Ofatumumab in Relapsing Multiple Sclerosis
Source: ClinicalTrials.gov · Last updated 10 Jun 2026
Brief summary (registry, in English)
This study aims to assess whether, and the degree to which, ofatumumab modulates or reduces rates of retinal atrophy in people with relapsing-remitting MS (RMS), according to baseline serum neurofilament light chain (sNfL) levels.
- Status (registry)
- Enrolling by invitation
- Study type
- Observational
- Enrollment
- 75 (estimated)
- First submitted
- 15 Nov 2023
- Start date
- 22 May 2023
- Primary completion date
- 31 Mar 2027
- Lead sponsor
- Johns Hopkins University
- Diseases
- Multiple sclerosis
- NCT number
- NCT06167642
What you commit to
- Study type: Observational
- Planned participants: 75
- From 22 May 2023 to the primary completion date, 31 Mar 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Uncontrolled Diabetes
- Uncontrolled Hypertension
- Other neurologic or ophthalmologic disorders
Other
- Glaucoma
- Refractive errors of +/- 6 diopters
Who the study is looking for
- Between 18 - 70 years of age
- Have RMS as confirmed by the treating neurologist based on the 2017 revised McDonald criteria
- AND Either
- be due to commence ofatumumab within 60 days of baseline OCT/VA/phlebotomy or
- be existing patients attending the center and already receiving ofatumumab, be eligible for inclusion, and already undergoing all of the proposed study procedures.
- Willing to sign informed consent
- Willing to undergo phlebotomy
Age in the registry: 18 years to 70 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Johns Hopkins Coordinator of this site? Confirm its status | Baltimore | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.