NCT06173947Recruiting
SSM Predicts Outcomes of CLD Inpatients With Acute Liver Injury
Spleen Stiffness Measurement Predicts Short-term Outcomes of Chronic Liver Disease Inpatients With Acute Liver Injury: a Prospective, Observational and Multicentre Study
Source: ClinicalTrials.gov · Last updated 21 May 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
In this study, a single non-invasive tool, spleen stiffness measurement (SSM), was used to monitor the disease regression of inpatients with chronic liver disease (CLD) and acute liver injury. The present study aimed to establish an early diagnosis warning model for acute-on-chronic liver failure (ACLF) by SSM and investigate the effect of dynamic changes in SSM on the short-term prognosis (28-day, 90-day morbidity and mortality) of inpatients with CLD and acute liver injury.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 411 (estimated)
- First submitted
- 24 Nov 2023
- Start date
- 1 Jan 2024
- Primary completion date
- 30 Sept 2025
- Lead sponsor
- Nanfang Hospital, Southern Medical University
- Diseases
- High blood pressure
- NCT number
- NCT06173947
What you commit to
- Study type: Observational
- Planned participants: 411
- From 1 Jan 2024 to the primary completion date, 30 Sept 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior surgery of liver diseases before enrollment such as liver transplantation, transjugular intrahepatic portosystemic shunt (TIPS), splenectomy and partial splenic embolization
- Severe extrahepatic diseases such as chronic obstructive pulmonary disease level IV, chronic kidney disease with end-stage renal failure, myocardial infarction within 3 months before admission
- Receiving Immunosuppressive drugs for reasons rather than chronic liver diseases
Other illness
- Diagnosis of hepatocellular carcinoma or other non-liver malignancies during screening period
- Serious mental illnesses such as anxiety, depressive disorders to obsessive-compulsive disorder (OCD) and post-traumatic stress disorder (PTSD)
Other
- The pregnant
- Jaundice due to biliary obstruction or cholestasis
- Unsuitable to participate in this study judging by investigators
Who the study is looking for
- Age between 18 years and 80 years
- Chronic liver diseases regardless of etiology
- Acute liver injury with total bilirubin ≥ 3 mg/dl regardless of inducement
Age in the registry: 18 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hepatology Unit, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University Coordinator of this site? Confirm its status | Guangzhou | China | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.