NCT06174389Recruiting
ADAPT Study: Assessing Diet, Appetite and Physiology Throughout Weight Loss Study)
Physiological Changes Underlying the Weight Loss Plateau in Human
Source: ClinicalTrials.gov · Last updated 29 Aug 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
Behavioral weight loss programs for obesity can result in weight loss and health benefits. However, behavioral weight loss often stops despite efforts to continue losing weight, this can be called an involuntarily weight loss plateau. This study investigates changes in metabolism and/or the brain that contribute to the occurrence of an involuntary weight loss plateau.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 90 (estimated)
- First submitted
- 13 Nov 2023
- Start date
- 1 Oct 2023
- Primary completion date
- 31 Jul 2027
- Lead sponsor
- University of Washington
- Diseases
- Obesity
- NCT number
- NCT06174389
What you commit to
- Study type: Interventional
- Planned participants: 90
- From 1 Oct 2023 to the primary completion date, 31 Jul 2027
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Heavy alcohol use (≥2 drinks/d for females, ≥3 drinks/d for males) or drug use
- Use of medications with significant effects on appetite (e.g., weight loss medications, atypical antipsychotics, stimulants) and/or chronic use of anticoagulants
- Prior or current participation in a research study involving weight loss
Other illness
- Known cognitive impairments or h/o stroke
- Type 2 diabetes (known diagnosis or by screening A1c (≥6.5%))
- Medical conditions (chronic diseases, cancer, MS) or labs limiting ability to participate
- History of bariatric surgery
- History of eating disorder
- Allergy or intolerance to or unwillingness to consume study foods provided at visit
- Any condition(s) found by the study team and confirmed with the PI(s) that make it unsafe to participate
Other
- Current smoker or regular use of nicotine containing products and/or cannabis
- Females: currently pregnant (or 6-months postpartum of full-term pregnancy) and/or current breastfeeding
- Current participation in a formal weight loss program
- Weight-reduced by \>10% within past year
- Weight \> 330 pounds (MRI limit)
- MRI contraindication (e.g., implanted metal, claustrophobia)
- Do not have a phone compatible with activity tracker or access to videoconferencing platform that will be used for the dietary intervention or other appropriate technology needed to complete study procedures
Who the study is looking for
- BMI 30.0 - 50.0 kg/m2
- Able to attend study intervention classes and study visits/assessments
- Independently living with access to food preparation facilities
Age in the registry: 18 years to 60 years · Sex: All · Accepts healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Fred Hutch Cancer Center Coordinator of this site? Confirm its status | Seattle | United States | Not yet recruiting |
| University of Washington - South Lake Union Coordinator of this site? Confirm its status | Seattle | United States | Recruiting |
Related publications
This page is information, not medical advice. Discuss any trial with your doctor.