NCT06176859Completed
Delivery Optimization for Pre-Exposure Prophylaxis (DO PrEP) Study
Delivery Optimization for Pre-Exposure Prophylaxis (DO PrEP) Study: A Prospective, Interventional, Randomized Study of Community-based PrEP Initiation, Delivery, and Monitoring in South Africa
Source: ClinicalTrials.gov · Last updated 10 Jul 2026
Brief summary (registry, in English)
The overall goal is to determine whether an end-to-end decentralized delivery service for PrEP is more effective, safe, acceptable, and cost-effective than facility-based PrEP delivery.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 2500 (actual)
- First submitted
- 22 Apr 2023
- Start date
- 17 Jul 2023
- Primary completion date
- 26 Mar 2026
- Lead sponsor
- Massachusetts General Hospital
- Diseases
- HIV
- NCT number
- NCT06176859
What you commit to
- Study type: Interventional
- Participants enrolled: 2500
- From 17 Jul 2023 to the primary completion date, 26 Mar 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- HIV infection based on negative HIV rapid tests
Other
- Clinically ineligible for PrEP
- The participant doesn't reside in the study community for the duration of follow-up
Who the study is looking for
- Aged 16 years - 30 years old,
- Self-report living without HIV or unknown status.
- Persons who have been sexually active within the last 3 months
- Interested in the use of PrEP for HIV prevention.
- Able and willing to provide informed consent for study procedures.
- Access to a cellphone for study related communication
- Reside in the study community for the duration of follow-up.
Age in the registry: 16 years to 30 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Human Sciences Research Council Coordinator of this site? Confirm its status | Durban | South Africa | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.