NCT06178952Recruiting
Transcranial Pulse Stimulation (TPS) in Post-COVID-19
Source: ClinicalTrials.gov · Last updated 23 Dec 2025
Brief summary (registry, in English)
The objective of the present study is to demonstrate treatment efficacy of transcranial pulse stimulation for patients with Post-COVID-19 related neurological symptoms (fatigue, cognitive deficits, mood deterioration). Fatigue, as measured by the Fatigue Impact Scale (FIS), will represent the primary outcome variable. The verum treatment will be compared to a sham (placebo) condition.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 102 (estimated)
- First submitted
- 20 Dec 2023
- Start date
- 8 Jan 2024
- Primary completion date
- 31 Jan 2027
- Lead sponsor
- Medical University of Vienna
- Diseases
- Long COVID and ME/CFS
- NCT number
- NCT06178952
What you commit to
- Study type: Interventional
- Planned participants: 102
- From 8 Jan 2024 to the primary completion date, 31 Jan 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Brain implants
- Relevant corticosteroid treatments administered within 6 weeks prior to the first application
Other illness
- Clinically relevant realization of pre-COVID diseases with similar symptoms as Post-COVID
- MoCA score \<17 (cut-off for dementia)
- Clinically relevant history of surgery on the head, heart, or vessels
- Blood clotting disorders
Other
- BDI-II score ≥29 (cut-off for severe depression)
- FIS \<10 (cut-off for no fatigue)
- Non-MR-compatible metal parts in the body
- Metal parts in the head
- Use of anticoagulants
- Non-MR-compatible claustrophobia
- Non-MR-compatible pacemaker
- Pregnant and breastfeeding women
- Tumor of the head if relevant for treatment
- Participation in other studies
Who the study is looking for
- Signed written informed consent
- PCR-confirmed SARS-CoV-2 infection, laboratory confirmed antibody detection for SARS-CoV-2, or physician-verified COVID-19 infection
- At least 12 months after initial SARS-CoV-2 infection that led to Post-COVID (subsequent SARS-CoV-2 infections are not a reason for exclusion)
- Diagnosis of Post-COVID Syndrome or independent suspected diagnosis of Post-COVID Syndrome (Considering that physicians generally hesitate to provide clear-cut Post-COVID diagnoses, a tentative diagnosis by an independent general practitioner or a specialist in a field associated with Post-COVID will suffice for entering this study)
- Age: 20-80
- Evidence of a negative pregnancy test if medically adequate
Age in the registry: 20 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Medical University of Vienna Coordinator of this site? Confirm its status | Vienna | Austria | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.