NCT06179212Recruiting
Exercise Testing Protocols for Females and Males With CAD
Comparing VO2 Peak Values of Exercise Testing Protocols for Females and Males With CAD
Source: ClinicalTrials.gov · Last updated 5 Oct 2026
Brief summary (registry, in English)
The aim of this study is to determine if the test that allows males to achieve a higher VO2 (a measure of oxygen use during exercise) is different for females. The purpose of this study is to test 4 different exercise testing protocols to compare measured oxygen consumption in females and males with CAD (disease caused by the buildup of plaque in the artery walls which can lead to insufficient amounts of blood, nutrients and oxygen being supplied to the heart). The 4 exercise tests that will be completed on the treadmill are the modified Balke, modified Bruce, modified Naughton and University of Ottawa Heart Institute Slow Ramp protocols. Each test has a different stage duration (the amount of time that the test remains at a pre-determined speed and incline), and incremental increase in speed and incline. The main purpose of this study is to compare VO2 peak (the maximal amount of oxygen utilized during the exercise test) of females and males with CAD in 4 different exercise protocols. For example, the investigators will find out: 1. which exercise protocol is more likely to achieve a higher peak V̇O2 in females and which protocol is more likely to achieve a higher peak V̇O2 in males, 2. if enjoyment affects the duration of the test, and 3. how different exercise test protocols will provide different results of maximal oxygen used by the participant's body during the exercise test.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 54 (estimated)
- First submitted
- 11 Dec 2023
- Start date
- 1 Mar 2024
- Primary completion date
- Dec 2028
- Lead sponsor
- Ottawa Heart Institute Research Corporation
- Diseases
- Coronary artery disease
- NCT number
- NCT06179212
What you commit to
- Study type: Observational
- Planned participants: 54
- From 1 Mar 2024 to the primary completion date, Dec 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- have recently changed (or planning to change) PA levels within the previous 4 weeks (as this may impact the ability to compare outcomes between exercise testing protocols);
Other illness
- have an arrythmia (relative contraindication for exercise testing),6 peripheral artery disease, valvular disease, severe aortic stenosis, cardiomyopathy, SCAD and/or COPD (contraindications for maximal exercise testing);
Lab values
- have heart failure with an ejection fraction \<45% (indication of possible cardiomyopathy);6
Other
- cannot speak, read, write, or understand English or French;
- currently not enrolled in a CR program;
- has an ICD;
- is pregnant (sustained vigorous exercise in pregnant women may induce fetal bradycardia)
- is unable to complete submaximal exercise testing (i.e., treadmill, due to musculoskeletal limitations).
Who the study is looking for
- 18 years and older;
- previous CAD diagnosis by a physician;
- can perform a CPET until volitional exhaustion;
- are able to self-ambulate on a treadmill;
- are at least 8 weeks post cardiovascular event or procedure (i.e., percutaneous coronary intervention (PCI), coronary artery bypass graft (CABG)); and,
- are able to provide written informed consent.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Ottawa Heart Institute Coordinator of this site? Confirm its status | Ottawa | Canada | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.