NCT06179329Recruiting
One-year Patency Comparison Between Radial Artery and No-touch Saphenous Vein Grafts in Women Undergoing Isolated CABG
No-Touch Saphenous Venous Harvesting TechniQue versUs Radial artEry in Coronary Artery Bypass Grafting in womEN: The QUEEN Multicenter Randomized Controlled Trial
Source: ClinicalTrials.gov · Last updated 12 Dec 2025
Brief summary (registry, in English)
The use of a graft from the left internal thoracic artery to the left anterior descending artery has become the gold standard for the indication of coronary artery bypass grafting. However, choosing a graft for the second-best coronary artery, focusing on long-term patency, is still a challenge. The saphenous vein using the "no-touch" technique is an alternative to a radial artery graft, but there is little evidence, especially in women. This randomized clinical study aims to compare the patency of these grafts in the second-best coronary artery in women undergoing coronary artery bypass grafting.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 150 (estimated)
- First submitted
- 6 Dec 2023
- Start date
- 1 Jan 2024
- Primary completion date
- 1 Jan 2025
- Lead sponsor
- University of Sao Paulo General Hospital
- Diseases
- Coronary artery disease
- NCT number
- NCT06179329
What you commit to
- Study type: Interventional
- Planned participants: 150
- From 1 Jan 2024 to the primary completion date, 1 Jan 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Inability to use the saphenous and/or radial vein
- Positive Allen test using a pulse oximeter
- Presence of abnormal flow detected by means of a Doppler exam in one of the grafts to be used.
- History of vasculitis or Raynaud's syndrome, varicose veins, or history of previous saphenous vein removal
Other illness
- Conditions that may affect patient follow-up
- Presence of advanced peripheral arterial disease
- Known contrast allergy: Presence of a documented allergy to the contrast agent used in radiological procedures.
- Impossibility of tracking due to geographic inaccessibility.
- Patients with lack of adherence to guidelines and/or prescribed medications.
Lab values
- Preoperative conditions:
- Lack of the patient's written informed consent.
- Presence of poorly controlled diabetes, with a glycated hemoglobin value \>8 mg/dl.
- Emergency or salvage surgery, where the intervention needs to be performed quickly due to the critical clinical condition of the patient.
- Renal failure with glomerular filtration rate (creatinine clearance) \<30 mL/min.
Who the study is looking for
- Women aged 18 years or older and younger than 75 years, undergoing isolated and primary myocardial revascularization surgery, with triarterial coronary artery disease (three vessels involved) in vessels subject to surgical revascularization and left ventricular ejection fraction greater than 35%. The target coronary vessels of the study will be those in the territory of the left circumflex artery and the right coronary artery, which must have at least 1.5 mm in diameter, and with proximal obstructive lesions of at least 70%.
Age in the registry: 18 years to 75 years · Sex: Female · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Instituto do Coração do Hospital das Clínicas da Faculdade de Medicina de São Paulo Coordinator of this site? Confirm its status | São Paulo | Brazil | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.