NCT06185686Recruiting
Radiation Induced Alterations in Resting State Brain Networks in Pediatric Brain Tumor Patients
Assessing Radiation Induced Alterations in Resting State Brain Networks in Pediatric Brain Tumor Patients
Source: ClinicalTrials.gov · Last updated 17 Jul 2026
Brief summary (registry, in English)
With modern therapy, the survival rate for pediatric brain tumor patients has significantly improved, with over 70% of patients surviving their disease. However, this progress often comes at the cost of substantial morbidity, with cognitive deficits being the primary obstacle to independent living. Robust predictors of cognitive decline and a comprehensive understanding of the underlying mechanisms of cognitive injury remain elusive. This study will prospectively investigate alterations in brain resting state networks following radiation therapy using functional imaging. The hypothesis is that radiation therapy leads to dose-dependent alterations in functional connectivity in the networks associated with higher level cognition, ultimately leading to cognitive decline.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 16 (estimated)
- First submitted
- 14 Dec 2023
- Start date
- 10 Jul 2024
- Primary completion date
- 31 Jul 2027
- Lead sponsor
- Washington University School of Medicine
- Diseases
- Childhood cancers
- NCT number
- NCT06185686
What you commit to
- Study type: Observational
- Planned participants: 16
- From 10 Jul 2024 to the primary completion date, 31 Jul 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Presence of visual impairment to an extent that the patient is unable to complete the computer testing
- Contraindication to MRI scan (i.e. due to cardiac pacemaker)
Other
- Presence of programmable shunt or dental braces
- Requires sedation for MRI scans
Who the study is looking for
- Between 8 and 21 years of age, inclusive
- Newly diagnosed primary brain tumor of any location and any histology that will be treated with proton radiation therapy
- Life expectancy of at least one year
- Able to understand and willing to consent or assent to the research proposed (or that of a legally authorized representative, if applicable), along with consent of legal guardian(s) if applicable
Age in the registry: 8 years to 21 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Washington University School of Medicine/Saint Louis Children's Hospital Coordinator of this site? Confirm its status | St Louis | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.