NCT06186102CompletedPhase 2
Polyamine Treatment in Elderly Patients With Coronary Artery Disease
Polyamine Treatment in Elderly Patients With Coronary Artery Disease - a Randomized Controlled Trial
Source: ClinicalTrials.gov · Last updated 1 Jul 2026
Brief summary (registry, in English)
The present study is testing spermidine treatment in elderly patients with coronary artery disease. The study is a randomized, double-blind, placebo-controlled, two-armed, parallel-group, single centre, clinical study.
- Status (registry)
- Completed
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 187 (actual)
- First submitted
- 7 Dec 2023
- Start date
- 1 Jan 2024
- Primary completion date
- 29 Jun 2026
- Lead sponsor
- University of Aarhus
- NCT number
- NCT06186102
What you commit to
- Study type: Interventional · Phase 2
- Participants enrolled: 187
- From 1 Jan 2024 to the primary completion date, 29 Jun 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Some metallic implants
- Treatment with either two antiplatelet drugs (aspirin and ADP-receptor antagonists)
Other illness
- Unstable coronary syndrome
- Significant and severe cardiac valve disease
- Severe peripheral artery disease
- Severe comorbidity as judged by the investigator (such as severe pulmonary, neurological, or musculoskeletal disease)
Lab values
- Chronic kidney disease with eGFR \<45 ml/min/1,73m2
Other
- Permanent atrial fibrillation
- Pacemaker treatment
- Inability to give informed consent.
- Claustrophobia
- Anticoagulants (warfarin, NOACs)
Who the study is looking for
- Age ≥ 65 years
- Chronic ischemic heart disease (previous revascularization or myocardial infarction)
- Left ventricular ejection fraction of \> 40%
- And at least two of the following risk factors:
- Type 2 diabetes,
- Obesity (BMI ≥ 30 kg/m2),
- Hypertension,
- Previous LVEF \< 40%,
- Left atrial volume index ≥ 30 mL/m2
- Left ventricular wall thickness ≥ 1.1 cm.
Age in the registry: 65 years to 90 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Aarhus University Hospital Coordinator of this site? Confirm its status | Aarhus | Denmark | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.