NCT06188065Recruiting
Eosinopenia in Severe COPD Exacerbation
Associates of, and Time to Recovery From, Eosinopenia in Severe COPD Exacerbation
Source: ClinicalTrials.gov · Last updated 14 Apr 2026
Brief summary (registry, in English)
The goals of this observational study are to identify factors independently associated with admission eosinopenia in patients with a severe exacerbation of chronic obstructive pulmonary disease (COPD) and to determine when blood eosinophil count (BEC) will recover to baseline stable state in patients who are admitted to hospital with a severe exacerbation of COPD and associated eosinopenia. The main aims of the study are to: 1. Identify demographic, physiological and clinical factors independently associated with admission eosinopenia in patients with a severe exacerbation of COPD 2. Assess the time to recovery from eosinopenia to stable BEC following a severe exacerbation of COPD
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 200 (estimated)
- First submitted
- 15 Dec 2023
- Start date
- 22 Jan 2024
- Primary completion date
- Jul 2026
- Lead sponsor
- Northumbria Healthcare NHS Foundation Trust
- Diseases
- COPD
- NCT number
- NCT06188065
What you commit to
- Study type: Observational
- Planned participants: 200
- From 22 Jan 2024 to the primary completion date, Jul 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Maintenance oral prednisolone or other systemic steroids, anti-interleukin 5 therapy or other medication known to influence eosinophils
Other illness
- Active malignancy
- Investigator confirmed history of asthma
Lab values
- Parasitic infection, systemic fungal infection (excluding infection limited to nails or skin), eosinophilic granulomatosis with polyangiitis, hypereosinophilic syndrome or other conditions associated with a high eosinophil count#
Other
- Patients with poor venous access
- Non-COPD related health problems which in the view of the primary investigator may compromise the conduct and completion of the study
- ADDITIONAL CRITERIA FOR THE TIME TO RECOVERY FROM EOSINOPENIA ANALYSIS ONLY
Who the study is looking for
- Admitted to hospital with primary clinical diagnosis of exacerbation of COPD\*
- Smoking history of at least 10 pack years
- Airflow obstruction: FEV1/FVC ratio \< 0.7 confirmed on historic or inpatient spirometry
- Capacity to give informed consent to participate
- Eosinopenia on admission
- Uneventful recovery\*
- Eosinopenia on admission who do not receive a further course of systemic corticosteroids or require emergency hospital admission for an acute illness in the six weeks following admission to hospital with a severe exacerbation of COPD.
Age in the registry: 35 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Northumbria Healthcare NHS Foundation Trust Coordinator of this site? Confirm its status | North Shields | United Kingdom | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.