NCT06190197RecruitingEarly phase 1
Prophylactic Antibiotics in Cystectomy With Diversion
Prophylactic Antibiotics in Radical Cystectomy With Urinary Diversion
Source: ClinicalTrials.gov · Last updated 17 Nov 2025
Brief summary (registry, in English)
Using a randomized 2 arm design, this study is being conducted to test for non-inferiority of no prophylactic antibiotic therapy versus the prophylactic oral antibiotic, nitrofurantoin, through comparison of rates of postoperative urinary tract infections within the 90-day postoperative period in patients with muscle invasive bladder cancer who undergo radical cystectomy with urinary diversion.
- Status (registry)
- Recruiting
- Phase (registry)
- Early phase 1
- Study type
- Interventional
- Enrollment
- 120 (estimated)
- First submitted
- 13 Dec 2023
- Start date
- May 2024
- Primary completion date
- Oct 2027
- Lead sponsor
- University of Minnesota
- Diseases
- Bladder cancer
- NCT number
- NCT06190197
What you commit to
- Study type: Interventional · Early phase 1
- Planned participants: 120
- From May 2024 to the primary completion date, Oct 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Currently receiving antimicrobials for active infection
- Prior pelvic radiation
Other illness
- Allergy to nitrofurantoin and unable to take an alternative antibiotic (cephalexin, trimethoprim-sulfamethoxazole, or ciprofloxacin)
Lab values
- Poor renal function with GFR \< 30 ml/min
Other
- Pregnancy
- Unable to provide Informed consent
Who the study is looking for
- Presence of muscle invasive bladder cancer and planning to undergo radical cystectomy with either ileal conduit or neobladder diversion.
- 18 years of age or older
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Minnesota Coordinator of this site? Confirm its status | Minneapolis | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.