NCT06202976Recruiting
Mapping Epileptic Networks Using Multimodal Imaging
Source: ClinicalTrials.gov · Last updated 17 Apr 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
Currently, mapping the epileptogenic zone is based on a comprehensive preoperative assessment involving clinical, imaging and electrophysiological examinations. To reduce the need for invasive stereoelectroencephalography (SEEG) explorations, electrophysiological and imaging methods have been developed, such as resting-state functional MRI (fMRI) coupled with electroencephalogram and arterial spin-labeling perfusion MRI (ASL-MRI). It has been published that these new methods enable precise delineation of the epileptogenic zone and better preparation for surgery. The aim is to determine whether, in children with focal lesional epilepsy, the combination of ASL-MRI-EEG and resting-state fMRI-EEG enables precise identification of the epileptogenic zone to be defined by SEEG, the current reference examination.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 75 (estimated)
- First submitted
- 2 Jan 2024
- Start date
- 14 Sept 2017
- Primary completion date
- 13 Sept 2033
- Lead sponsor
- Imagine Institute
- Diseases
- Epilepsy
- NCT number
- NCT06202976
What you commit to
- Study type: Observational
- Planned participants: 75
- From 14 Sept 2017 to the primary completion date, 13 Sept 2033
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Have generalized epilepsy
Other
- Requiring general anesthesia for MRI
- Require sedation specifically for research
- Be deprived of liberty or under guardianship.
Who the study is looking for
- Be under 18 years of age on the day of inclusion.
- Present with one of the following forms of epilepsy:
- refractory focal lesional epilepsy
- rare non-lesional epilepsy
- Present abnormalities (spikes) on the intercritical EEG
- Have been selected by the "Epilepsy" multidisciplinary staff.
- In the case of refractory lesional epilepsy, be required to perform an EEG-video recording using intracranial electrodes (SEEG) as part of the pre-surgical workup.
- Be affiliated to a health insurance scheme.
Age in the registry: - to 18 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Necker-Enfants Malades Hospital Coordinator of this site? Confirm its status | Paris | France | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.