NCT06205771Enrolling by invitation
The Role and Mechanism of GPER-Hippo-CBS/H2S Pathway in Preeclampsia
The Role and Mechanism of GPER Hippo Pathway in Regulating Uterine Arterial Smooth Muscle CBS/H2S in the Pathogenesis of Preeclampsia
Source: ClinicalTrials.gov · Last updated 10 Apr 2024 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
The goal of this clinical trial is to learn about in health conditions. The main questions it aims to answer are: * The pathological significance of GPER in uterine artery dilation in preeclampsia * The Mechanism of GPER Hippo Pathway Regulating CBS/H2S in Human Uterine Artery Smooth Muscle Cells (hUASMC) This project intends to use GPER interfering RNA, YAP1 interfering RNA, in vivo perfusion experiments of human uterine artery tissue, and single cell patch clamp technology to study hypotheses under physiological/pathological pregnancy conditions at the tissue, cellular, and molecular levels, revealing a novel signal transduction pathway of estrogen stimulating vasodilation, providing new ideas for studying the mechanism of uterine artery blood flow regulation. This research result will provide new targets for intervention and treatment of diseases such as fetal intrauterine growth retardation and preeclampsia.
- Status (registry)
- Enrolling by invitation
- Study type
- Interventional
- Enrollment
- 54 (estimated)
- First submitted
- 4 Jan 2024
- Start date
- 10 Apr 2024
- Primary completion date
- 31 Oct 2029
- Lead sponsor
- Hao Feng
- NCT number
- NCT06205771
What you commit to
- Study type: Interventional
- Planned participants: 54
- From 10 Apr 2024 to the primary completion date, 31 Oct 2029
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Combined with chronic hypertension, kidney disease, intrahepatic cholestasis, etc Other basic diseases;
Other
- Multiple pregnancy
- Pregnant women undergoing vaginal delivery
- Normal pregnant women who are\<37 weeks or\>40 weeks pregnant
Who the study is looking for
- Full term pregnancy with clinical diagnosis of preeclampsia and normal pregnancy pregnant woman
- Pregnant women undergoing lower segment cesarean section for delivery
Age in the registry: - to 40 years · Sex: Female · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| The First Affiliated Hospital of Shandong First Medical University (Shandong Provincial Qianfoshan Hospital) Coordinator of this site? Confirm its status | Jinan | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.