NCT06207136Recruiting
Microbiome and Diet in Parkinson's Disease
Canadian Parkinson's Microbiome Initiative: A Pilot Phase 2 Feasibility Randomized Controlled Trial of the MIND Diet in Parkinson's Disease
Source: ClinicalTrials.gov · Last updated 23 Mar 2026
Brief summary (registry, in English)
The goal of this pilot study is to examine the feasibility and effects of an 18-month intervention diet compared to an active control diet (standard diet) in those living with Parkinson's Disease (PD), without dementia. Research has shown that eating components of Mediterranean diets are associated with a 30% lower risk to develop PD and a 40% lower mortality rate in those living with PD. Diet may influence the gut and microbiomes, thus may affect PD risk and progression. This study will examine how easy it will be to adhere to a certain type of diet for 18 months and what changes may occur in the gut microbiome and in PD symptoms on a specific diet during that time. The study will involve in-person study visits at UBC as well as online diet coaching sessions and online group cooking classes over Zoom. This is a randomized study, meaning that participants will be assigned by chance to either the Mediterranean-style diet group or the standard diet group for the duration of the 18 months. This pilot study will also examine recruitment rates and retention, in order to prepare for a larger future study.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 40 (estimated)
- First submitted
- 5 Jan 2024
- Start date
- 3 Dec 2024
- Primary completion date
- 31 Dec 2027
- Lead sponsor
- University of British Columbia
- Diseases
- Parkinson disease
- NCT number
- NCT06207136
What you commit to
- Study type: Interventional
- Planned participants: 40
- From 3 Dec 2024 to the primary completion date, 31 Dec 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- used Probiotics in the last 4 weeks prior to study start,
- used Antibiotics in the last 3 months prior to study start,
Other illness
- medical or psychiatric conditions that would prevent full participation in the nutrition intervention (such as food allergies), significant dysphagia, diabetes on insulin, anti-coagulation on warfarin, and inflammatory bowel disease,
- clinical dementia,
Other
- Not eligible, if person has/is:
- a diagnosis of atypical parkinsonism,
- unable to complete questionnaires or understand study instructions,
- using of immunomodulatory agents,
- contraindications for MRI.
Who the study is looking for
- Eligible if the person living with Parkinson's has/is:
- a clinical diagnosis of PD,
- cognitively stable (no clinical dementia),
- between 40-80 years old,
- able to travel to UBC for 6 onsite visits over 18 months,
- sufficient English proficiency (coaching and cooking classes are in English only),
- on a stable dopaminergic medication for at least one month before baseline,
- computer and internet access at home, and can be available via video link for at least 80% of the study sessions.
Age in the registry: 40 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| UBC Pacific Parkinson's Research Centre Coordinator of this site? Confirm its status | Vancouver | Canada | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.