NCT06208163Completed
The Effects of Chiropractic in a Population With High Central Adiposity
Psychoneuroimmunology as a Framework for Studying the Effects of Chiropractic Care in a Population With High Central Adiposity: a Pilot Trial
Source: ClinicalTrials.gov · Last updated 8 May 2026
Brief summary (registry, in English)
Since 1980, the global prevalence of obesity, commonly defined as a body mass index (BMI) of 30 or higher, has doubled. Importantly, high levels of central adiposity (i.e., abdominal fat) is associated with numerous PNI-related sequelae, including increased levels of psychological distress, cognitive deficits, ANS dysfunction, and immune marker abnormalities. To our knowledge, rigorous investigation of chiropractic's impact on psychoneuroimmunological (PNI)-related outcomes in people with high central adiposity is lacking. Based on limited evidence to date, it is plausible that clinically important PNI-related dysfunctions (e.g., heightened stress levels, executive function impairments, dysautonomia, immune dysregulation) common in this population could be ameliorated via chiropractic care.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 18 (actual)
- First submitted
- 5 Jan 2024
- Start date
- 11 Nov 2024
- Primary completion date
- 4 Sept 2025
- Lead sponsor
- Life University
- Diseases
- Obesity
- NCT number
- NCT06208163
What you commit to
- Study type: Interventional
- Participants enrolled: 18
- From 11 Nov 2024 to the primary completion date, 4 Sept 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- If taking prescription medications, other than short-acting benzodiazepines, not on a stable dose for a minimum of 6 weeks with plans to change medications or doses during the study
Other illness
- Known disorder resulting in syncope/fainting during postural changes (e.g., POTS, orthostatic hypotension)
- Pacemaker or known heart condition that influences the electrical or mechanical function of the heart (e.g., severe heart valve disease)
- Diagnosed with externalizing (e.g., substance use, antisocial disorder) or thought (e.g., schizophrenia, paranoid personality, bipolar) disorder that is uncontrolled or untreated
- Hearing impairment (cognitive task uses auditory stimuli)
- Oral injury, inflammation, or disease that causes the mouth or gums to bleed easily
Other
- Had chiropractic care within the past 30 days
- Prescribed short-acting benzodiazepines which include midazolam \& triazolam
- Not able to walk unassisted on a treadmill
- Diagnosed with rheumatoid arthritis, osteoporosis, or cervical spine instability
- Currently pregnant
- Current litigation related to a physical, health-related injury
- Whiplash injury in the past 3 months
Who the study is looking for
- 18-65 years of age
- Body mass index (BMI) at least 30
- Waist circumference at least 35 inches if female or 40 inches if male
Age in the registry: 18 years to 65 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Life University Coordinator of this site? Confirm its status | Marietta | United States | Unknown status |
Related publications
- Psychoneuroimmunological changes in adults with obesity receiving chiropractic care: a single-arm pilot trial.Front Psychiatry · 2026 · PMID 42540508
This page is information, not medical advice. Discuss any trial with your doctor.