NCT06214065Recruiting
Modulating Temporoparietal Junction Mentalizing-Related Activity in Autism Spectrum Disorder (ASD) Using Transcranial Magnetic Stimulation (TMS)
Modulating Temporoparietal Junction Mentalizing-Related Activity in Autism Spectrum Disorder Using Transcranial Magnetic Stimulation
Source: ClinicalTrials.gov · Last updated 27 Mar 2026
Brief summary (registry, in English)
The goal of this observational study is to test the modulation effect of different transcranial magnetic stimulation (TMS) on the neural network supporting our ability to create mental representations of others (also known as mentalizing) in young adults with autism. The main question it aims to answers is can stimulation of the right temporoparietal junction can change brain activity related to mentalizing during social interaction in the stimulation area and other brain areas connected to it. Researchers will compare results to a group of individuals without autism to see if the patterns of neural activity change are similar between the groups. Participants will undergo assessment of their clinical traits and social skills and baseline MRI scan. They will attend three additional visits that include TMS session and functional MRI scans before and right after TMS.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 80 (estimated)
- First submitted
- 9 Jan 2024
- Start date
- 3 Apr 2024
- Primary completion date
- 31 Oct 2027
- Lead sponsor
- Yale University
- Diseases
- Autism
- NCT number
- NCT06214065
What you commit to
- Study type: Interventional
- Planned participants: 80
- From 3 Apr 2024 to the primary completion date, 31 Oct 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
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Who the study is looking for
- Estimated full-scale IQ\>80
- Right handed
- Fluent in English
- Individual can cooperate with all study's procedures
- No history of neurological disorder (e.g. epilepsy) or neurosurgery
- No major medical condition (e.g. cancer, heart failure)
- No history of significant head injury
- No primary relatives with history of any neurological disorder with a potentially hereditary basis, including epilepsy or MS
- No current use of medications with psychotropic (e.g., benzodiazepines) or anti- or pro-convulsants
- No current substance use (determined by urine screen and breathalyzer in all visits)
- Negative urine pregnancy (women) test at time of MRI scans
- No MR contra-indications (e.g. in-body metal implant, severe claustrophobia)
- No previous participation in our lab in a study including the Domino fMRI task
- For ASD: Stable medication treatment 4 weeks prior to study enrollment
- For Control Group: No current or history of psychiatric disorders, other than simple phobia, and/or primary relatives with ASD
Age in the registry: 18 years to 35 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Olin Neuropsychiatry Research Center (ONRC) Coordinator of this site? Confirm its status | Hartford | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.