NCT06214910Completed
ThiPhiSA: New Pathways to Prevention From Community TB Screening in South Africa
Source: ClinicalTrials.gov · Last updated 30 Jul 2026
Brief summary (registry, in English)
This study will compare community-delivered, multi-month dispensing of tuberculosis preventive therapy (TPT) to standard-of-care clinic-based TPT delivery in a population of South African adults who are recommended to receive TB preventive therapy. We hypothesize that persons receiving multi-month dispensing of TPT in the community will have a higher rate of TPT completion at 3 months than persons receiving TPT via standard of care with monthly clinic-based refills.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 301 (actual)
- First submitted
- 8 Jan 2024
- Start date
- 20 Feb 2024
- Primary completion date
- 30 May 2025
- Lead sponsor
- University of Washington
- Diseases
- Tuberculosis, HIV
- NCT number
- NCT06214910
What you commit to
- Study type: Interventional
- Participants enrolled: 301
- From 20 Feb 2024 to the primary completion date, 30 May 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Currently on TB treatment
Age
- Less than 18 years of age.
Other
- Pregnant or planning on pregnancy within next three months
- Planning on moving or relocating from the area within the next three months
- Positive for active TB
Who the study is looking for
- ≥18 years of age
- Living in the study catchment area
- Eligible for TPT according to South African National guidelines(5), i.e. are a) living with HIV or b) are a close contact of a person with TB disease (defined by a person that resides in the same house as a person with TB), c) and in either case
- Have screened negative for TB disease in the last 6 months, through TB TRIAGE+ Trial, other household contact tracing, or other community TB screening
- Negative TB screening at enrolment (if TB TRIAGE+ screening was more than 3 months ago)
- Willing and able to provide written or verbal consent
- Participants whom have not received TPT in the last 12 months; this was confirmed verbally with participants during the enrolment process.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Human Sciences Research Council Coordinator of this site? Confirm its status | Sweetwaters | South Africa | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.