NCT06215703Completed
Optimizing Music-Based Interventions for Stroke
Optimizing Music-based Interventions for Stroke: a Mechanistic Crossover Study of the Effects of Music Improvisation and Live Accompaniment on Motor, Autonomic, and Neural Response During a Music Playing Task Among Survivors of Stroke and Matched Healthy Control Participants
Source: ClinicalTrials.gov · Last updated 25 Apr 2025
Brief summary (registry, in English)
This study will enroll stroke patients and healthy participants. Participants will complete baseline measures followed by a music playing task during fMRI and simultaneous measurement of motor response using electromyography (EMG) and accelerometry and affective response using electrodermal activity (EDA) and self-reports. The music task consists of tapping an MRI-compatible MIDI drum with either: (1) improvisation or maintaining the beat and (2) live or recorded piano accompaniment. The primary objectives are to identify the motor, affective, and neural outcomes of improvisation and live accompaniment in music playing tasks.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 26 (actual)
- First submitted
- 11 Jan 2024
- Start date
- 16 Feb 2024
- Primary completion date
- 8 Feb 2025
- Lead sponsor
- NYU Langone Health
- Diseases
- Stroke
- NCT number
- NCT06215703
What you commit to
- Study type: Interventional
- Participants enrolled: 26
- From 16 Feb 2024 to the primary completion date, 8 Feb 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- not being compatible with MRI testing, including having implanted devices, previous exposure to metallic fragments, large tattoos, claustrophobia, and pregnancy
Other illness
- history of neurological injury other than stroke
- visual impairment unable to be corrected with glasses/contact lenses sufficient to allow reading comprehension
Other
- moderate to severe depression symptoms indicated by a score \>10 on the Patient Health Questionnaire - 9 (PHQ-9; Koenke et al., 2001; Williams et al., 2005)
- actively performing or practicing a musical instrument more than 2 hours/week
- musical anhedonia indicated by a score \< 65 on the Barcelona Music Reward Questionnaire (BMRQ; Mas-Herrero et al., 2013)
- amusia as measured by the Montreal Battery of the Evaluation of Amusia (MBEA; Peretz et al., 2003)
Who the study is looking for
- For participants with stroke, to be eligible to participate in this study, an individual must meet all the following criteria:
- hemiparesis resulting from a stroke (ischemic or hemorrhagic) at least 6 months before the enrollment into the study
- age from 18 to 89 years
- ability to move the wrist flexor and extensor muscles without help from the healthy side, scoring above 3 on the Medical Research Council (MRC) Scale for Muscle Strength, reflecting active movement against gravity
- no more than mild resistance to passive movement in the wrist extensor muscle - as demonstrated by a score \<2 on the Ashworth Scale (Brashear et al.., 2002)
- a modified Rankin Scale (mRS) \< 3 indicating moderate to mild disability and the ability to ambulate independently (Bonita \& Beaglehole, 1988)
- ability to comprehend language and provide informed consent
- consenting to participate and willingness to complete MRI testing procedures
- For neurologically normal control (NC) participants, to be eligible to participate in this study, an individual must meet all the following criteria:
- be matched for age, gender, and socioeconomic status (education level) to a previously enrolled participant with stroke
- age from 18 to 89 years
- no history of neurological injury
- ability to comprehend language and provide informed consent
- consenting to participate and willingness to complete MRI testing procedures
Age in the registry: 18 years to 89 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| NYU Langone Health Coordinator of this site? Confirm its status | New York | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.