NCT06220721Recruiting
Reducing the Risk of Chronic Hypertension and Improving Vascular Function Following Preeclampsia
Source: ClinicalTrials.gov · Last updated 20 Jul 2026
Brief summary (registry, in English)
The long-term goal of our work is to evaluate the effect of intensive postpartum blood pressure control on maternal cardiovascular health, risk of chronic hypertension, and reversal of vascular dysfunction generated by hypertensive disorders of pregnancy, thus attenuating the lifelong trajectory of cardiovascular disease risk.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 618 (estimated)
- First submitted
- 15 Jan 2024
- Start date
- 23 Oct 2024
- Primary completion date
- 31 Mar 2029
- Lead sponsor
- Medical College of Wisconsin
- Diseases
- High blood pressure
- NCT number
- NCT06220721
What you commit to
- Study type: Interventional
- Planned participants: 618
- From 23 Oct 2024 to the primary completion date, 31 Mar 2029
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Already taking long-acting antihypertensive medication for standard care
Other illness
- Pre-gestational hypertension
- Type 1 or type 2 diabetes mellitus
- Known allergy or contraindication to nifedipine ER
- Maternal conditions that impact study outcomes: sickle cell disease, systemic lupus erythematosus
Other
- Admitted to intensive care unit at the time of screening
- Diagnosed with HDP during postpartum readmission after discharge from delivery hospitalization
- Getting discharged on the day of screening
- Inability or unwillingness to provide informed consent
Who the study is looking for
- Hypertensive disorders of pregnancy (HDP) diagnosis, specifically gestational hypertension, preeclampsia, eclampsia, or HELLP syndrome, according to ACOG guidelines
- Postpartum day 0-4
- Age ≥ 18 years
- Able to communicate in English or in Spanish
- Has an established OBGYN at an MCW or NU health system practice that has access to Epic electronic medical records.
Age in the registry: 18 years to - · Sex: Female · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Northwestern University Coordinator of this site? Confirm its status | Chicago | United States | Recruiting |
| Medical College of Wisconsin Coordinator of this site? Confirm its status | Milwaukee | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.