NCT06223035Completed
Myokine Identification Following Acute Exercise
Identification of Exercise-induced Myokines Regulating the Muscle-adipose Signaling Axis
Source: ClinicalTrials.gov · Last updated 10 Mar 2025
Brief summary (registry, in English)
Exercise stimulates a cascade of responses within the human body. For example, exercise results in the release of proteins into the circulation which communicate with cells and organs throughout the body. In fact, recent human research identified more than 600 proteins are released into the blood circulation following short-term exercise, many of which are predicted to come from the skeletal muscle and target the fat tissue. However, identification of these muscle-secreted proteins and their target tissue (i.e. fat tissue) remains extremely challenging. This challenge is because tissue needs to be collected from multiple sites (skeletal muscle and fat) and at multiple timepoints (before and after exercise). This study seeks to address these challenges through the collection of fat and blood both before and after short-term exercise followed by protein detection (of the blood) and gene expression (of the fat tissue).
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 12 (actual)
- First submitted
- 30 Nov 2023
- Start date
- 18 Apr 2024
- Primary completion date
- 9 Aug 2024
- Lead sponsor
- Rockefeller University
- NCT number
- NCT06223035
What you commit to
- Study type: Interventional
- Participants enrolled: 12
- From 18 Apr 2024 to the primary completion date, 9 Aug 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- recent surgery of the upper or lower extremities (any surgeries in past 6 months at the ankle or foot, or in the past year at the knee, hip, shoulder or elbow)
- any prior sensations of chest pain during exercise.
- individuals who are currently taking exogenous hormones
- individuals who chronically consume NSAIDS or other anti-inflammatory medication (every day for the previous 3 months)
Other illness
- Any medical condition that in the opinion of the investigator will confound interpretation of data for analysis.
Other
- unhealed fractures
- thrombophlebitis (blood clots)
- recent uncontrolled bruising
- recent muscle, bone or joint damage which interferes with regular physical activity
- taking part in vigorous physical activity more than 3 times per week
- individuals who are pregnant as determined by an on-site pregnancy test
- failing the PARQ questionnaire as indicated by answering "YES" to any of the questions
- Having a BMI \>32
Who the study is looking for
- passing the PARQ questionnaire (i.e. answering "NO" to all questions)
- being between the ages of 18-45
- being moderately active (defined as participating in 30 minutes of recreational activity at least once per week for the past 3 months but no more than 3 times per week)
- non-smoking
- free of metabolic or cardiovascular diseases
Age in the registry: 18 years to 45 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Rockefeller University Coordinator of this site? Confirm its status | New York | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.