NCT06223074Enrolling by invitationPhase 2
Improving the Treatment of Acute Relapses in Multiple Sclerosis Through Intranasal Methylprednisolone Administration
Towards the Improvement of the Treatment of Acute Relapses in Multiple Sclerosis: A Randomized Double-blind, Non-inferiority Controlled Trial Comparing Intranasal Versus Intravenous Methylprednisolone
Source: ClinicalTrials.gov · Last updated 3 Apr 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
This Clinical Trial evaluates the nasal administration of Methylprednisolone as a treatment strategy for Acute Relapses in Multiple Sclerosis
- Status (registry)
- Enrolling by invitation
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 80 (estimated)
- First submitted
- 25 Apr 2023
- Start date
- 9 Jan 2023
- Primary completion date
- 25 Feb 2026
- Lead sponsor
- Universidad Nacional Autonoma de Mexico
- Diseases
- Multiple sclerosis
- NCT number
- NCT06223074
What you commit to
- Study type: Interventional · Phase 2
- Planned participants: 80
- From 9 Jan 2023 to the primary completion date, 25 Feb 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Intake of anti-inflammatory steroids in the last 3 days.
Other illness
- Patients with active bacterial, viral or fungal infections or undergoing treatment.
- Patients with hypertension.
- Patients with diabetes mellitus.
- Diagnosis of systemic diseases such as: cardiovascular, pulmonary, hepatic, endocrine, gastrointestinal, etc.
- Patients with a history of resistance to glucocorticoids.
- Patients with a history of severe adverse reactions to glucocorticoids.
- Patients with a history of hyposmia or anosmia.
- Patients with allergic rhinitis.
- Patients with upper respiratory tract infections.
- History of nasal surgery.
Lab values
- Patients with suspected or confirmed pregnancy by means of serum or urinary laboratory tests.
Other
- Patients with hypo or hyperthyroidism.
- Patients with glaucoma.
- Patients with neoplasms.
- Breastfeeding patients.
- Patients diagnosed with active sinusitis.
- deviated septum
Who the study is looking for
- Age between 18 and 65 years.
- Diagnosis of RRMS with an evolution from diagnosis of 3 months to 10 years.
- Kurtzke Expanded Disability Status Scale (EDSS) from 1 to 6 (grade 6 includes patients with unilateral aid to ambulate)
- No contraindication for the administration of MP.
- Agree to participate in the study by means of a signed informed consent
Age in the registry: 18 years to 65 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Instituto Nacional de Neurologia y Neurocirugia Coordinator of this site? Confirm its status | Mexico City | Mexico | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.