NCT06223828RecruitingPhase 2/3
Azithromycin for Critical Asthma - Pediatrics
Azithromycin as Immunomodulation Among Children Hospitalized for Critical Asthma: A Prospective, Open-Label, Non-Randomized, Interventional Study With Parallel Biospecimen Banking
Source: ClinicalTrials.gov · Last updated 11 Aug 2026
Brief summary (registry, in English)
The CR-AZI Study will assess the immunomodulatory effects of Azithromycin for pediatric Critical Asthma.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 2/3
- Study type
- Interventional
- Enrollment
- 100 (estimated)
- First submitted
- 16 Jan 2024
- Start date
- 2 Apr 2024
- Primary completion date
- 31 Dec 2026
- Lead sponsor
- Johns Hopkins All Children's Hospital
- Diseases
- Asthma
- NCT number
- NCT06223828
What you commit to
- Study type: Interventional · Phase 2/3
- Planned participants: 100
- From 2 Apr 2024 to the primary completion date, 31 Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Concomitant respiratory pathology including Acute Chest Syndrome, Interstitial Lung Disease, Cystic Fibrosis, and pulmonary hypertension
Other illness
- Critical Congenital Heart Disease Unrepaired
Lab values
- Past Medical History of Prolonged QT Syndrome or Arrhythmias
Other
- Tracheostomy Dependence at Admission
- Ongoing Exposure to Azithromycin or Macrolide Antibiotics for any indication
Who the study is looking for
- Age 3-17 years
- Admission to the PICU
- Primary diagnosis of critical asthma
- Prescription for continuous inhaled beta-agonist therapy and/or intravenous (IV) beta-agonist therapy
- Prescription for intravenous systemic corticosteroids
Age in the registry: 3 years to 17 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Johns Hopkins All Children's Hospital Coordinator of this site? Confirm its status | St. Petersburg | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.