NCT06226493Recruiting
EEG Changes and DNA Markers Related to taVNS in Stroke Patients: a Preliminary Study
EEG Changes and DNA Markers Related to Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) in Acute Stroke Patients: a Preliminary Study
Source: ClinicalTrials.gov · Last updated 31 Mar 2026
Brief summary (registry, in English)
In the United States, more than 795,000 people have a stroke every year. Motor impairment after a stroke is common and can be debilitating. To date, there remain few treatments available to help improve motor recovery after a stroke, making this an important area of research. Novel use of neuromodulation such as Invasive Vagus Nerve Stimulation (VNS) has been shown to improve motor recovery in stroke patients. Vagus nerve stimulation (VNS), in which the nerve is stimulated with electrical pulses, has demonstrated success for a variety of conditions, including inflammation, depression, cognitive dysfunction, chronic fatigue, headaches/migraines, pain, insomnia, and cardiovascular issues. Very recently, non-invasive options have been developed and might be a promising alternative. The research in this area is still very limited and much more research is needed to investigate non-invasive/trancutaneous auricular vagus nerve stimulation (taVNS) related biomechanisms and to further support its efficacy in acute patients. The purpose of this study is to build upon the current research to investigate changes in electrical brain activity (using electrophysiology) and genetic markers related to improvements in both motor and cognitive recovery following the use of taVNS vs. sham in acute stroke patients.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 44 (estimated)
- First submitted
- 10 Jan 2024
- Start date
- 29 Jan 2024
- Primary completion date
- 1 Jan 2027
- Lead sponsor
- Casa Colina Hospital and Centers for Healthcare
- Diseases
- Stroke
- NCT number
- NCT06226493
What you commit to
- Study type: Interventional
- Planned participants: 44
- From 29 Jan 2024 to the primary completion date, 1 Jan 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous surgical intervention on the vagus nerve
- Alcohol or drug abuse
Other illness
- Advanced cardiac, pulmonary, liver, or kidney disease
- Other musculoskeletal or neurologic diseases that could interfere with the outcome measures
Other
- Bradycardia (Resting HR \< 60)
- Presence of Apraxia, Aphasia or confusion
- Participation in other clinical trials
Who the study is looking for
- First-time Cerebrovascular Accident (Ischemic or Hemorrhagic)
- Within a month post-injury
- Presence of motor impairments (FMA-U≤62)
Age in the registry: 18 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Casa Colina Hospital and Centers for Healthcare Coordinator of this site? Confirm its status | Pomona | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.