A Study of LY3841136 Compared With Placebo in Adult Participants With Obesity or Overweight

Prior treatment

• Have any prior diagnosis of diabetes mellitus except gestational diabetes.
• Have any of the following cardiovascular conditions within 6 months prior to screening:
  • acute myocardial infarction
  • cerebrovascular accident (stroke)
  • unstable angina, or
  • hospitalization due to congestive heart failure (CHF).
• Have a prior or planned surgical treatment for obesity, except prior liposuction or abdominoplasty, if performed \>1 year prior to screening.

Other illness

• Have a history of acute or chronic pancreatitis.
• Have an on-going or history of bradyarrhythmia and/or sinus bradycardia at screening and baseline.
  • W8M-MC-CWMM
• Have type 1 diabetes mellitus, latent autoimmune diabetes in adults, or history of ketoacidosis or hyperosmolar coma.
• Have poorly controlled hypertension.
• Have a history of symptomatic gallbladder disease within the past 2 years
• Have signs and symptoms of any liver disease other than nonalcoholic fatty liver disease.
• Have a lifetime history of suicide attempts.

Other

• W8M-MC-LAA1

• W8M-MC-LAA1
• Are males and females who agree to abide by the reproductive and contraceptive requirements
  • W8M-MC-CWMM:
• Have a body mass index (BMI)
  • ≥30 kilogram/square meter (kg/m²), or
  • ≥27 kg/m² and \<30 kg/m², or with at least 1 weight-related comorbidity
• Have had a stable body weight for the 3 months prior to randomization (\<5%) body weight gain and/or loss.