NCT06230965Completed
Clinical Study of Lung Protective Ventilation Strategies and Tumor Microenvironment
Effect of Lung Protective Ventilation Strategy on Tumor Inflammatory Microenvironment and Its Associated Hematological Composite Index in Patients Undergoing Colorectal Cancer Surgery
Source: ClinicalTrials.gov · Last updated 25 Mar 2026
Brief summary (registry, in English)
This study will be conducted in the Affiliated Hospital of Nantong University. Sixty colorectal cancer(CRC) patients are randomized into traditional ventilation strategy group (control group) and lung protective ventilation strategy group (experimental group), there were 30 cases in each group. The control group adopted conventional ventilation strategy; the experimental group used lung protective ventilation strategy. 4ml of central venous blood was extracted at 3 time points within 24h, and relevant experimental indexes were determined. Observe the effect of lung protective ventilation strategy on the microenvironment of tumor inflammation and related hematological indexes in patients undergoing colorectal cancer surgery. Follow-up frailty score and quality of recovery score at 1,3,6, and 12 months after surgery (QoR-15 score scale).
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 60 (actual)
- First submitted
- 9 Jan 2024
- Start date
- 25 Jan 2024
- Primary completion date
- 1 Feb 2025
- Lead sponsor
- Affiliated Hospital of Nantong University
- Diseases
- Lung cancer, Colorectal cancer
- NCT number
- NCT06230965
What you commit to
- Study type: Interventional
- Participants enrolled: 60
- From 25 Jan 2024 to the primary completion date, 1 Feb 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- A history of pulmonary infection and pulmonary tuberculosis within 1 month before surgery;
- Patients who take immunosuppressants, neoadjuvant chemotherapy and radiotherapy before surgery;
Lab values
- Preoperative anemia (hemoglobin\<10g/dl)
Other
- Patients with preoperative mechanical ventilation;
- Preoperative blood oxygen saturation (SpO₂) was less than 90% (SpO₂\<90%), or the oxygen partial pressure (PaO₂) was less than 90% (PaO₂\<60 mmHg), or PaO₂/fraction of inspired oxygen（FiO₂）ratio\<300 mmHg, or arterial blood carbon dioxide partial pressure (PaCO₂) was greater than 45 mmHg (PaCO₂\>45 mmHg);
- Preoperative abnormal coagulation function.
Who the study is looking for
- pathologic diagnosis of Colorectal Cancer
- American society of Aneshesiologists（ASA）physical status classification system Grade Ⅱ-Ⅲ;
- From 51-70 years old with no gender restrictions
- Normal cardiopulmonary function before operation
- Body Mass Index:18-30
Age in the registry: 51 years to 75 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| The Affiliated hospital of Nantong University Coordinator of this site? Confirm its status | Nantong | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.