NCT06232629Active, not recruiting
Towards Noninvasive DBS of the Basal Ganglia in Parkinson's Disease Using TUS
Towards Noninvasive Deep Brain Stimulation of the Basal Ganglia in Parkinson's Disease Using Low-intensity Transcranial Ultrasound Stimulation
Source: ClinicalTrials.gov · Last updated 15 Sept 2025
Brief summary (registry, in English)
Transcranial Ultrasound Stimulation (TUS) is an emerging non-invasive brain stimulation technique capable of targeting both superficial and deep brain areas with high spatial resolution, down to a few cubic millimeters. In this study, the investigators aim to use TUS to non-invasively modulate the globus pallidus internus (GPi) in patients with Parkinson's disease (PD) and dystonia. These patients have previously been implanted with deep brain stimulation (DBS) leads. The investigators plan to simultaneously record local field potentials (LFPs) from the DBS leads using the Percept PC device (Medtronic Inc.) while the DBS is turned off. The study's goal is to investigate the mechanism of action of TUS and its neuromodulatory effects on LFPs recorded from the GPi. This will enable us to compare the effects of TUS with those of DBS.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 10 (estimated)
- First submitted
- 26 Dec 2023
- Start date
- 1 Aug 2023
- Primary completion date
- 31 Dec 2025
- Lead sponsor
- University Health Network, Toronto
- Diseases
- Parkinson disease
- NCT number
- NCT06232629
What you commit to
- Study type: Interventional
- Planned participants: 10
- From 1 Aug 2023 to the primary completion date, 31 Dec 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Concomitant neurological conditions (stroke, seizure, dementia, major depression / psychiatric disorders, active drug abuse/addiction and major neuromuscular/musculoskeletal diseases)
Other illness
- Implants (cardiac pacemaker, implantable cardioverter-defibrillator, intracranial devices other than DBS system such as shunts and MR- unsafe devices)
- History of intracranial lesioning procedures
- Major systemic illness, infection or pregnancy
Other
- Declined cognitive scores (MoCA score \< 22)
Who the study is looking for
- Adult patients with movement disorders (diagnosed by a movement disorder specialist)
- Implantation of a Percept PC DBS system at least one month before the sonications
- Stable dopaminergic medication dose for a minimum of 4 weeks
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Toronto Western Hospital Coordinator of this site? Confirm its status | Toronto | Canada | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.