NCT06234995RecruitingPhase 4
Cortical Electrophysiology of Response Inhibition in Parkinson's Disease
Source: ClinicalTrials.gov · Last updated 3 Sept 2026
Brief summary (registry, in English)
Patients with Parkinson's Disease will be studied before, during, and after a deep brain stimulation implantation procedure to see if the stimulation location and the size of the electrical field produced by subthalamic nucleus (STN) DBS determine the degree to which DBS engages circuits that involve prefrontal cortex executive functions, and therefore have a direct impact on the patient's ability to inhibit actions.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 4
- Study type
- Interventional
- Enrollment
- 80 (estimated)
- First submitted
- 23 Jan 2024
- Start date
- 9 Aug 2021
- Primary completion date
- Sept 2027
- Lead sponsor
- Emory University
- Diseases
- Parkinson disease
- NCT number
- NCT06234995
What you commit to
- Study type: Interventional · Phase 4
- Planned participants: 80
- From 9 Aug 2021 to the primary completion date, Sept 2027
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- inability to hold antiparkinsonian medications for research recordings
- inability to hold antiparkinsonian medications for research recordings
- inability to tolerate temporary discontinuation of DBS therapy or alteration of stimulation settings for research purposes
- history of a neuropsychiatric disorder and/or treatment with psychotropic medications
Other illness
- dementia
- uncontrolled hypertension
- heart disease
- other medical conditions considered to increase the patient's risk for surgical complications
- other medical conditions considered to increase the patient's risk for surgical complications
Other
- severe tremor at rest or severe dyskinesia which would cause significant artifacts in electrophysiological signals
- non-English speaker
- presence of a coagulopathy
- severe tremor at rest or severe dyskinesia which would cause significant artifacts in electrophysiological signals
- non-English speaker
Who the study is looking for
- diagnosis of idiopathic Parkinson's disease (PD)
- Hoehn and Yahr (H\&Y) stage 2-4 (off medication)
- diagnosis of idiopathic PD
- there is a clinical indication for DBS surgery
- normal preoperative MRI
- ability to tolerate microelectrode-guided neurosurgery in an awake state
- diagnosis of idiopathic PD
- functioning DBS system
- age 45-75
Age in the registry: 45 years to 75 years · Sex: All · Accepts healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Emory University Hospital Coordinator of this site? Confirm its status | Atlanta | United States | Recruiting |
| Emory Brain Health Center Coordinator of this site? Confirm its status | Atlanta | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.