NCT06236256Completed
Advanced Hybrid Closed Loop System (AHCL) in Older Patients With Type 1 Diabetes Mellitus
Advanced Hybrid Closed Loop System (780G) for People With Type 1 Diabetes Mellitus Patients Over the Age of 60: Efficacy in Improving Glucose Indices, Quality of Life, Cognitive Functions and Physical Capacity
Source: ClinicalTrials.gov · Last updated 21 Jul 2026
Brief summary (registry, in English)
The trial is a randomized controlled, parallel group design study. Patients will be followed up during approximatively 12 months. Patients will be randomized to either the MDI/CSII group which will continue their treatment as per routine procedures and the advanced Hybrid Closed Loop system (AHCL) group which will be connected to the Minimed 780G system. . At the end of the 12 month study period, we will evaluate whether the AHCL system improved glucose indices in older individuals with Type 1 diabetes mellitus (T1DM) and assess whether the ACHL treatment improved physical capacity, frailty \& sarcopenia indices as well as quality of life and cognitive functions.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 42 (actual)
- First submitted
- 14 Nov 2023
- Start date
- 9 Jan 2024
- Primary completion date
- 20 Aug 2025
- Lead sponsor
- Sheba Medical Center
- Diseases
- Type 1 diabetes
- NCT number
- NCT06236256
What you commit to
- Study type: Interventional
- Participants enrolled: 42
- From 9 Jan 2024 to the primary completion date, 20 Aug 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Severe concurrent illness
Other illness
- Severe renal impairment
- Any illness that may interfere with study procedures
Lab values
- Laboratory abnormalities, or medications that might affect study participation,
Who the study is looking for
- Age over 60 years
- T1DM
- Willing to participate in a study for the specified duration
- Willing to perform ≥ 4 finger stick blood glucose measurements daily or connected to a "basket approved" CGM
- Willing to wear the system continuously throughout the study
- Treated with MDI/CSII (with exclusion of 780G or other hybrid closed systems)
- Lack of advanced complications of diabetes
Age in the registry: 60 years to 120 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Sheba medical center Coordinator of this site? Confirm its status | Ramat Gan | Israel | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.