NCT06241651Recruiting
CSP Versus BiVP for Heart Failure Patients With RVP Upgraded to Cardiac Resynchronization Therapy
Conduction System Pacing Versus Biventricular Pacing for Heart Failure Patients With Right Ventricular Pacing Upgraded to Cardiac Resynchronization Therapy: a Prospective Multicenter Non-inferiority Randomized Controlled Study
Source: ClinicalTrials.gov · Last updated 14 May 2026
Brief summary (registry, in English)
The present study is a prospective, multicenter, non-inferiority, randomized controlled trail. It aims to investigate whether the efficacy of conduction system pacing (CSP) is non-inferior to biventricular pacing (BiVP) in patients with heart failure and right ventricular pacing (RVP) requiring upgrading to cardiac resynchronization therapy (CRT).
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 66 (estimated)
- First submitted
- 19 Jan 2024
- Start date
- 1 Jan 2024
- Primary completion date
- Mar 2027
- Lead sponsor
- The First Affiliated Hospital with Nanjing Medical University
- Diseases
- Heart failure
- NCT number
- NCT06241651
What you commit to
- Study type: Interventional
- Planned participants: 66
- From 1 Jan 2024 to the primary completion date, Mar 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- History of acute myocardial infarction within 3 months before enrollment;
- History of valvular heart disease intervention within 3 months before enrollment;
Other illness
- Frequent premature ventricular contraction (\>15%) or malignant ventricular arrhythmia which is difficult to control;
- Complex congenital heart disease;
- History of heart transplantation;
Other
- After mechanical tricuspid valve replacement;
- Ventricular septal hypertrophy (≥15mm during diastole);
- Enrollment in any other study;
- Pregnant or with child-bearing plan;
- A life expectancy of less than 12 months.
Who the study is looking for
- Patients with symptomatic heart failure (LVEF \<50%) after right ventricular pacing for at least 3 months;
- NYHA class II-IV;
- NT-proBNP \>125pg/mL in patients with sinus rhythm, NT-proBNP \>250pg/mL in patients with atrial fibrillation;
- Right ventricular pacing percentage \>40%;
- Adult patients aged 18-80;
- With informed consent signed.
Age in the registry: 18 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| The First Affiliated Hospital with Nanjing Medical University Coordinator of this site? Confirm its status | Nanjing | China | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.