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NCT06247774Not yet recruiting

Reducing Heart Failure Risk in Late-Life With Physical Activity

Reducing Heart Failure Risk in Late-Life With Physical Activity: Impact on Cardiac Structure and Function and Proteomic Signatures

Source: ClinicalTrials.gov · Last updated 12 Mar 2026

Brief summary (registry, in English)

The goal of this clinical trial is to learn about the molecular pathways associated with the benefit of a regular exercise program in patients with high blood pressure and who don't already participate in regular exercise. The main question it aims to answer is to identify protein signatures associated with the benefits of a cardiac rehabilitation exercise program. The trial will enroll 42 participants, who will be randomized to a 12 week cardiac rehabilitation exercise program versus control arm and asked to participate in the following at the beginning and end of study: * Cardiopulmonary exercise test (CPET) * Echocardiogram * Physical function test * 6-minute walk test * Hand grip strength * Quality of life questionnaire * Blood draws Researchers will compare results between those who do and don't participate in the exercise program.

Status (registry)
Not yet recruiting
Study type
Interventional
Enrollment
42 (estimated)
First submitted
23 Jan 2024
Start date
Jun 2026
Primary completion date
Jan 2029
Lead sponsor
Brigham and Women's Hospital
NCT number
NCT06247774

What you commit to

  • Study type: Interventional
  • Planned participants: 42
  • From Jun 2026 to the primary completion date, Jan 2029
  • No sites listed in no country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Other illness

  • Diabetes
  • Pulmonary hypertension
  • Devices that limit ability to achieve target heart rate
  • Moderate to severe valve disease
  • Terminal illness, life expectancy \<6 months

Other

  • Unable to exercise
  • Supplemental oxygen use
  • Sleep apnea
  • Regular exercise training
  • Recent (within 3 months) major CV event or planned procedures (within 6 months)
  • Inability or unwillingness to comply with study requirements
  • No access to smart phone/tablet

Who the study is looking for

  • Hypertension (controlled on stable medication regimen)
  • Structural heart abnormality (LVH or LA enlargement)
  • LVEF \> 50%
  • Sedentary
  • BMI \<30

Age in the registry: 65 years to - · Sex: All · Accepts healthy volunteers

Full criteria on ClinicalTrials.gov

This page is information, not medical advice. Discuss any trial with your doctor.