NCT06252532Enrolling by invitation
Causal Role of Top-Down Theta Oscillations in Prioritization
Modulating Oscillations and Working Memory in Patients With Subdural Electrodes
Source: ClinicalTrials.gov · Last updated 19 Aug 2026
Brief summary (registry, in English)
Purpose: The purpose of this pilot study is to investigate the dynamics between theta and alpha oscillations in the control of working memory. These findings will be informative of what types of brain stimulation are most effective at modulating brain activity. Deep brain stimulation and transcranial magnetic stimulation are used for an increasing number of neurological and psychiatric disorders. Participants: Eligible participants are patients who have previously had electrodes implanted to monitor epilepsy (outside of research activity). 50 participants will be recruited, 25 participants for each phase of the study. Procedures (methods): The participants will perform a cognitive control task. During the task, rhythmic trains of direct cortical stimulation will be delivered to the frontal cortex alone or to the frontal and parietal cortex. Electrocorticography will be collected concurrent with stimulation.
- Status (registry)
- Enrolling by invitation
- Study type
- Interventional
- Enrollment
- 50 (estimated)
- First submitted
- 1 Feb 2024
- Start date
- Jul 2024
- Primary completion date
- Jan 2027
- Lead sponsor
- University of North Carolina, Chapel Hill
- Diseases
- Epilepsy
- NCT number
- NCT06252532
What you commit to
- Study type: Interventional
- Planned participants: 50
- From Jul 2024 to the primary completion date, Jan 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Current diagnosis of other neurological illnesses including ischemic stroke, intracerebral hemorrhage, brain neoplasm
- Major systemic illness
- Severe cognitive impairment - diagnosed by clinician in neuropsychiatric evaluation
- Severe psychiatric illness
Other
- Excessive use of alcohol or other substances
- Anything that, in the opinion of the investigator, would place the participant at increased risk or preclude the participant's full compliance with or completion of the study
Who the study is looking for
- Able to provide informed consent
- History of medically intractable epilepsy
- Speak and understand English
- For the stimulation session, the participant must have electrodes in the relevant locations
Age in the registry: 18 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of North Carolina at Chapel Hill Coordinator of this site? Confirm its status | Chapel Hill | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.