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NCT06257212CompletedPhase 4

Live Vaccines and Innate Immune Training in COPD.

Using Live Vaccines to Induce Beneficial Innate Immune Training and Reduce Systemic Inflammation in COPD Patients.

Source: ClinicalTrials.gov · Last updated 19 Mar 2026

Brief summary (registry, in English)

A randomized, single-blinded clinical pilot study to assess whether vaccination with live attenuated vaccines can induce trained immunity and cause beneficial changes in patients with COPD.

Status (registry)
Completed
Phase (registry)
Phase 4
Study type
Interventional
Enrollment
60 (actual)
First submitted
6 Feb 2024
Start date
28 Feb 2024
Primary completion date
25 Aug 2025
Lead sponsor
Josefin Eklöf
Diseases
COPD
NCT number
NCT06257212

What you commit to

  • Study type: Interventional · Phase 4
  • Participants enrolled: 60
  • From 28 Feb 2024 to the primary completion date, 25 Aug 2025
  • 1 site in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Known allergy to BCG or MMR vaccines or serious adverse effects at previous vaccination.
  • Known prior, active, or latent infection with mycobacterium tuberculosis.
  • Vaccination with a live vaccine within the last 4 weeks.
  • Oral or intravenous corticosteroid at dose of ≥10 mg/day with duration over 3 months.
  • Treatment with immunoglobulins within the last 3 months or expected treatment with immunoglobulins for the duration of the trial.

Other illness

  • Acute febrile illness.
  • Allergy to MMR vaccine components, neomycin, or egg proteins.
  • Being severely immunocompromised (HIV-1 infection, organ- or bone marrow transplantation, chemotherapy, primary immune defect, anti-cytokine therapy, immunosuppressant treatment).
  • Active solid or non-solid malignancy or lymphoma, excluding basal cell carcinoma within 2 years.

Other

  • Pregnancy or breastfeeding.

Who the study is looking for

  • Specialist verified and spirometry-confirmed COPD
  • Age \> 40 years.
  • Negative HIV-test.
  • Able to give informed consent.

Age in the registry: 40 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Save your city in your profile to sort them by distance.

SiteCityCountrySite status
Department of Internal Medicine, Section of Respiratory Medicine
Coordinator of this site? Confirm its status		HellerupDenmarkUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.