NCT06257329Recruiting
Characteristics and Outcomes of Patients Admitted to ICU for a Severe Acute Exacerbation of COPD.
Epidemiological, Clinical and Biological Characteristics, and Therapeutic Management of ICU Patients With Severe Acute Exacerbation of COPD. Evaluation of Prognosis and Factors Associated With Survival.
Source: ClinicalTrials.gov · Last updated 27 Oct 2026
Brief summary (registry, in English)
The objective of this prospective observational study is to describe the epidemiological, clinical and biological characteristics of patients admitted in ICU for a severe acute exacerbation of COPD, and to assess the different treatment received received, to evaluate the prognosis with short, mid and long term ( 1 year) mortality and the factors associated with survival.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 2000 (estimated)
- First submitted
- 6 Feb 2024
- Start date
- 1 Oct 2022
- Primary completion date
- 1 Oct 2027
- Lead sponsor
- Alexis FERRE
- Diseases
- COPD
- NCT number
- NCT06257329
What you commit to
- Study type: Observational
- Planned participants: 2000
- From 1 Oct 2022 to the primary completion date, 1 Oct 2027
- 4 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Known asthma (according to the criteria of the international "Global initiative for asthma" guidelines)
- Patient refusal to participate (information note, application for non-opposition)
Who the study is looking for
- Age ≥ 40 years old
- COPD documented or strongly suspected
- Chronic respiratory symptoms (dyspnoea, cough and/or sputum)
- Exposure to a known risk factor for COPD (such as tobacco smoke)
- If available, respiratory function tests showing non- or partially reversible obstructive syndrom (post-bronchodilator ratio FEV1/CV \< 0.7)
- Severe acute exacerbation, defined as a worsening of the patient's usual respiratory symptoms with signs of acute respiratory distress (polypnoea ≥ 30 cycles.min-1 or use of accessory respiratory muscles) and/or hypercapnic acidosis (with PaCO2 ≥ 45 mmHg and pH ≤ 7.35)
- Admission to an ICU, a step-up unit or a respiratory care unit
Age in the registry: 40 years to - · Sex: All · Does not accept healthy volunteers
Sites (4)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| CHU de Grenoble Coordinator of this site? Confirm its status | Grenoble | France | Recruiting |
| Centre Hospitalier de Versailles Coordinator of this site? Confirm its status | Le Chesnay | France | Recruiting |
| CH Le Mans Coordinator of this site? Confirm its status | Le Mans | France | Recruiting |
| CHU Rennes Coordinator of this site? Confirm its status | Rennes | France | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.