NCT06263920Recruiting
Neurofrailty: A Study of Late-onset Epilepsy and Its Associations
A Prospective Population-based Longitudinal Observational Cohort Study of Late-onset Epilepsy, and Subsequent Stroke and Dementia.
Source: ClinicalTrials.gov · Last updated 8 Apr 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
There is not much known about why some people develop seizures in adulthood, but some researchers think that it might be a warning from the body to highlight something may be wrong with the brain. A small number of people with first seizure in adulthood go on to experience problems like stroke or dementia later in life. However, stroke and dementia are common diseases, so it is not know whether there is a real association between these conditions. When people develop their first seizure in adult life, this is sometimes called Late-Onset Epilepsy. The NeuroFrailty study, will observe 'brain health' over the years following the onset of a seizure, to provide more information about people with these kinds of seizures.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 360 (estimated)
- First submitted
- 9 Feb 2024
- Start date
- 5 May 2022
- Primary completion date
- 12 Jan 2027
- Lead sponsor
- Lancashire Teaching Hospitals NHS Foundation Trust
- NCT number
- NCT06263920
What you commit to
- Study type: Observational
- Planned participants: 360
- From 5 May 2022 to the primary completion date, 12 Jan 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- a 'lesional' attributable cause for seizures including malignancy, stroke (excluding transient ischaemic attack), hypoxic brain injury, trauma, vascular or congenital abnormality of likely aetiological significance.
- people with migraine or headache syndrome can be included in case group - the presence or absence of a seizure syndrome is mutually exclusive between case and control groups, not the presence or absence of migraine.
- diagnosis of epilepsy or confirmed seizure.
- 'lesional' attributable cause for seizures including malignancy, stroke (excluding transient ischaemic attack), hypoxic brain injury, trauma.
Who the study is looking for
- diagnosis of LOE or first seizure after the age of 18.
- diagnosis confirmed or established at a tertiary neurology centre.
- sequential cases will be used; in the unlikely event that eligible cases outstrip capacity, an annual cap of the first 150 patients per year per cohort will be used.
- established diagnosis of migraine.
- with or without therapeutic medications with antiepileptic properties.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Lancashire Teaching Hospitals NHS Coordinator of this site? Confirm its status | Preston | United Kingdom | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.