Surgical-imaging Research on Obesity (SIRO)

Prior treatment

• Unable to undergo surgery as planned;
• Alcohol or drug dependence;
• Contraindications for MR scanning (pacemakers, cochlear implants, metal objects in the body, claustrophobia, weight exceeding the machine's load limit, etc.);
• Use of drugs affecting the nervous system or psychotropic drugs within the last six months.

Other illness

• Secondary obesity caused by other organic diseases or medication (such as hormone use, etc.);
• Eating disorders;
• Meeting the criteria for organic mental disorders, severe mental disorders (schizophrenia, etc.), or other serious mental illnesses requiring clinical intervention;
• History of neurological organic diseases (brain tumors, epilepsy, cerebrovascular accidents, severe head trauma, etc.);
• History of congenital heart disease (myocardial infarction, severe arrhythmias, heart failure, cardiomyopathy, rheumatic heart disease, congenital heart disease, etc.);
• Severe liver, kidney, lung, digestive dysfunction, endocrine, and blood system diseases;
• Active infections within the last two weeks (fever, upper respiratory infection, acute gastroenteritis, etc.);

Other

• Pregnant or breastfeeding;
• Low cognitive ability and incapable of cooperating with the study;
• The same criteria as points 3) to 13) above.

• Meeting the obesity criteria (BMI \> 28); 2) Meeting the indications for bariatric surgery, planning to undergo surgery for the first time; 3) Age between 18-65 years old, no gender restrictions; 4) Right-handed, of Han ethnicity; 5) Informed consent to the study, willing to cooperate with the research, and able to sign an informed consent form.
• Healthy volunteers with a BMI between 18.5-23.9;
• Age between 18-65 years old, no gender restrictions;
• Right-handed, of Han ethnicity;
• Informed consent to the study, willing to cooperate with the research, and able to sign an informed consent form.