NCT06268626Recruiting
Detection of Endometrial Cancer Through Risk Modelling
Non-Invasive Strategies for Early Detection of Uterine Cancer in Patients With Abnormal Uterine Bleeding
Source: ClinicalTrials.gov · Last updated 16 Apr 2026
Brief summary (registry, in English)
The study goal is to investigate a non-invasive approach to predict endometrial cancer (EC) risk, better understand disease progression and identify opportunities for intervention. This two-part case-cohort prospective study will recruit patients whose abnormal uterine bleeding is being evaluated via endometrial biopsy. Participants will complete an online health questionnaire, and a subset will be invited to self-collect vaginal samples for sequencing. Selected sequenced participants will be invited for longitudinal monitoring (questionnaires, wearable fitness tracker) and an additional vaginal self-collection to identify persistent genetic mutations or microbiome alterations 6-8 months later.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 1000 (estimated)
- First submitted
- 30 Jan 2024
- Start date
- 10 Oct 2024
- Primary completion date
- Jan 2027
- Lead sponsor
- University of British Columbia
- Diseases
- Endometrial cancer
- NCT number
- NCT06268626
What you commit to
- Study type: Observational
- Planned participants: 1000
- From 10 Oct 2024 to the primary completion date, Jan 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Started hormone therapy (HRT, birth control, IUD) in the past year (with the exception of tamoxifen)
Other illness
- Endometrial sampling, pelvic radiation, or vaginal infection (vaginosis, yeast) in the past 3 months
Other
- Study Part A:
- Intercourse, vaginal product use, or douching in the past 48 hours
- Study Part B/Longitudinal monitoring:
- Same as Study Part A
- EC or EIN, or anyone who is recommended a hysterectomy
Who the study is looking for
- Study Part A:
- 40 years and older
- Experiencing unexplained abnormal uterine bleeding (i.e., not from IUD, etc.)
- Have an intact uterus
- Referred for an endometrial biopsy
- Study Part B/Longitudinal monitoring:
- Those selected for sequencing (from Part A) and who retained their uterus.
Age in the registry: 40 years to - · Sex: Female · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| VGH Research Pavilion Coordinator of this site? Confirm its status | Vancouver | Canada | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.