NCT06270576Not yet recruitingPhase 1
Nasal Inflammation Following Endotoxin Challenge in Patients With Asthma
Nasal Endotoxin Challenge to Study Mucosal Inflammation in Patients With Asthma
Source: ClinicalTrials.gov · Last updated 21 Feb 2024 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
A phase I clinical research study aimed at determining mechanisms that regulate airway mucosal inflammation in asthma endotypes using intranasal administration of endotoxin (lipopolysaccharide from E. coli) in healthy controls and subjects diagnosed with asthma.
- Status (registry)
- Not yet recruiting
- Phase (registry)
- Phase 1
- Study type
- Interventional
- Enrollment
- 60 (estimated)
- First submitted
- 30 Jan 2024
- Start date
- Apr 2024
- Primary completion date
- Apr 2028
- Lead sponsor
- National Jewish Health
- Diseases
- Asthma
- NCT number
- NCT06270576
What you commit to
- Study type: Interventional · Phase 1
- Planned participants: 60
- From Apr 2024 to the primary completion date, Apr 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Presence or prior history of cardiac or systemic disease
Other illness
- Current or recent illness (in the past 4 weeks)
- History of nasal perforation or nasal surgery
- Bleeding disorder, use of systemic anticoagulants, or antiplatelet therapy
- Immunocompromised state (HIV, immunoglobulin deficiency, systemic immunosuppressants excluding corticosteroids)
Other
- Recent asthma exacerbation (past 4 weeks)
- Nasal polyposis
- Use of tobacco or marijuana in the past 2 months or greater than a 10 pack-year smoking history
- Currently pregnant or breastfeeding
Who the study is looking for
- Participants will have asthma diagnosed by a health care provider. Healthy controls are individuals without asthma.
- Written informed consent
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| National Jewish Health Coordinator of this site? Confirm its status | Denver | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.