NCT06271941Recruiting
Reducing Neoplasia Recurrence After Endoscopic Resection of Large Colorectal Polyps
Source: ClinicalTrials.gov · Last updated 18 Sept 2026
Brief summary (registry, in English)
Large (≥20mm) colorectal polyps often harbor areas of advanced neoplasia, making them immediate colorectal cancer (CRC) precursors. Such polyps have to be completely removed to prevent CRC and to avoid surgery and/or adjuvant therapy. The laterally spreading lesions (LSLs) are removed via endoscopic mucosal resection (EMR). However, recurrence is common. New techniques for LSL resection (hybrid argon plasma coagulation (h-APC) margin and base ablation) have shown a reduction in recurrence following the interventions. We hypothesize that performing hybrid argon plasma coagulation (h-APC) margin and base ablation during EMR of large (≥20mm) colorectal LSLs will lead to lower rates of lesion recurrence compared to Snare tip soft coagulation (STSC) margin ablation.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 892 (estimated)
- First submitted
- 15 Feb 2024
- Start date
- 19 Jul 2024
- Primary completion date
- 1 Oct 2027
- Lead sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
- Diseases
- Colorectal cancer
- NCT number
- NCT06271941
What you commit to
- Study type: Interventional
- Planned participants: 892
- From 19 Jul 2024 to the primary completion date, 1 Oct 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- inflammatory bowel disease;
- overt signs of deep submucosal invasive cancer (JNET 3);
Lab values
- coagulopathy or thrombocytopenia (international normalized ratio ≥1.5 or platelets \<50 x 109/L);
Other
- non-elective colonoscopy;
- poor general health (American Society of Anesthesiologists classification \>III);
- pedunculated polyps (Paris class Ip, Isp);
- biopsy proven invasive carcinoma in a potential study polyp.
- Pregnant women
Who the study is looking for
- adult ≥18 years old
- patients undergoing EMR for a large (≥20mm) colorectal LSL
- patients providing written and informed consent for study participation.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Centre Hospitalier de l'Université de Montréal Coordinator of this site? Confirm its status | Montreal | Canada | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.