NCT06272461Recruiting
Comparison of Intravenous Lidocaine vs Ketamine in Colorectal Surgery
The Effect of Intravenous Lidocaine or Ketamine on Interleukin-6 Levels in Patients Undergoing Colorectal Surgery for Cancer: A Randomized Controlled Trial
Source: ClinicalTrials.gov · Last updated 18 Nov 2025
Brief summary (registry, in English)
Patients undergoing open colorectal surgery were randomly divided into two groups: Intravenous Lidocaine (IV-Lido) vs Intravenous Ketamine (IV-Keta). For the IV-Lido group, patients received a loading dose of Lidocaine than a continuous infusion over twenty-four hours. For the IV-Keta goup, patients received a loading dose of Ketamine than a continuous injection of Ketamine over twenty-four hours. Plasma concentrations of Interleukin-6(IL-6) were measured preoperatively before anesthetic induction and at twenty-four hour post operatively.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 50 (estimated)
- First submitted
- 19 Jan 2024
- Start date
- 1 Oct 2023
- Primary completion date
- 10 Feb 2026
- Lead sponsor
- University Tunis El Manar
- Diseases
- Colorectal cancer
- NCT number
- NCT06272461
What you commit to
- Study type: Interventional
- Planned participants: 50
- From 1 Oct 2023 to the primary completion date, 10 Feb 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Duration of surgery longer than 5 hours.
Other
- Severe intraoperative complications.
Who the study is looking for
- Patients aged 18 or older.
- American society of anesthesiologists' (ASA) physical status of I-III.
- Elective open colorectal surgery.
- NON INCLUSION CRITERIA:
- Patients with contraindications to lidocaine or ketamine.
- Corticosteroid therapy within the last 6 months.
- History of immunosuppressive therapy.
- History of surgery in the last 3 months.
- Personal medical history of inflammatory bowel disease.
- Personal medical history of cardiac arrythmias or conduction disorders.
- Alcohol or drug abuse.
- Chronic use of opioids or benzodiazepines.
Age in the registry: 18 years to 90 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Tunisia Coordinator of this site? Confirm its status | Nabeul | Tunisia | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.