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NCT06272487CompletedPhase 2

Zilebesiran as Add-on Therapy in Patients With High Cardiovascular Risk and Hypertension Not Adequately Controlled by Standard of Care Antihypertensive Medications (KARDIA-3)

A Randomized, Double-blind, Placebo-controlled, Multicenter Study to Evaluate the Efficacy and Safety of Zilebesiran Used as Add-on Therapy in Adult Patients With High Cardiovascular Risk and Hypertension Not Adequately Controlled by Standard of Care Antihypertensive Medications

Source: ClinicalTrials.gov · Last updated 2 Mar 2026

Brief summary (registry, in English)

The purpose of this study is to evaluate the effect of zilebesiran as add-on therapy in patients with high cardiovascular risk and hypertension not adequately controlled by standard of care antihypertensive medications.

Status (registry)
Completed
Phase (registry)
Phase 2
Study type
Interventional
Enrollment
375 (actual)
First submitted
15 Feb 2024
Start date
29 Feb 2024
Primary completion date
19 Jun 2025
Lead sponsor
Alnylam Pharmaceuticals
NCT number
NCT06272487

What you commit to

  • Study type: Interventional · Phase 2
  • Participants enrolled: 375
  • From 29 Feb 2024 to the primary completion date, 19 Jun 2025
  • 166 sites in 6 countries
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Other illness

  • Secondary hypertension

Lab values

  • Serum potassium \>4.8 milliequivalents per liter (mEq/L)

Other

  • Orthostatic hypotension
  • Proteinuria \>3 g/day

Who the study is looking for

  • History of cardiovascular (CV) disease, high CV risk, or estimated glomerular filtration rate (eGFR) ≥30 to \<60 mL/min/1.73m\^2
  • Mean seated office SBP ≥140 mmHg and ≤170 mmHg
  • 24-hour mean SBP ≥130 mmHg and ≤170 mmHg assessed by ABPM
  • Must be on stable therapy with 2 to 4 classes of antihypertensive medications

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (166)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
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BlacktownAustraliaUnknown status
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BrookvaleAustraliaUnknown status
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BruceAustraliaUnknown status
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ConcordAustraliaUnknown status
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GarranAustraliaUnknown status
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KanwalAustraliaUnknown status
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KogarahAustraliaUnknown status
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PerthAustraliaUnknown status
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Sippy DownsAustraliaUnknown status
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St LeonardsAustraliaUnknown status
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TarragindiAustraliaUnknown status
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BramptonCanadaUnknown status
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ChicoutimiCanadaUnknown status
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Greenfield ParkCanadaUnknown status
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MontrealCanadaUnknown status
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QuébecCanadaUnknown status
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QuébecCanadaUnknown status
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Sainte-FoyCanadaUnknown status
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SarniaCanadaUnknown status
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TorontoCanadaUnknown status
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Trois-RivièresCanadaUnknown status
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WaterlooCanadaUnknown status
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WinnipegCanadaUnknown status
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BaselSwitzerlandUnknown status
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GenevaSwitzerlandUnknown status
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LausanneSwitzerlandUnknown status
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LucerneSwitzerlandUnknown status
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BellshillUnited KingdomUnknown status
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BirminghamUnited KingdomUnknown status
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BristolUnited KingdomUnknown status
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CanterburyUnited KingdomUnknown status
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CardiffUnited KingdomUnknown status
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CarshaltonUnited KingdomUnknown status
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ChesterfieldUnited KingdomUnknown status
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ChorleyUnited KingdomUnknown status
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FoweyUnited KingdomUnknown status
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GlasgowUnited KingdomUnknown status
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HexhamUnited KingdomUnknown status
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LeicesterUnited KingdomUnknown status
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LiskeardUnited KingdomUnknown status
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LiverpoolUnited KingdomUnknown status
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LondonUnited KingdomUnknown status
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LutonUnited KingdomUnknown status
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ManchesterUnited KingdomUnknown status
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NewquayUnited KingdomUnknown status
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PickeringUnited KingdomUnknown status
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PlymouthUnited KingdomUnknown status
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TorpointUnited KingdomUnknown status
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PoncePuerto RicoUnknown status
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Toa BajaPuerto RicoUnknown status
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AcworthUnited StatesUnknown status
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AlbuquerqueUnited StatesUnknown status
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Alexander CityUnited StatesUnknown status
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AtlantaUnited StatesUnknown status
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AustinUnited StatesUnknown status
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BerlinUnited StatesUnknown status
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BethlehemUnited StatesUnknown status
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Beverly HillsUnited StatesUnknown status
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BoiseUnited StatesUnknown status
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BostonUnited StatesUnknown status
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BurkeUnited StatesUnknown status
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BurlingtonUnited StatesUnknown status
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CharlotteUnited StatesUnknown status
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ChattanoogaUnited StatesUnknown status
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ChicagoUnited StatesUnknown status
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ClearwaterUnited StatesUnknown status
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ClevelandUnited StatesUnknown status
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Colorado SpringsUnited StatesUnknown status
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ColumbusUnited StatesUnknown status
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CoppellUnited StatesUnknown status
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Coral GablesUnited StatesUnknown status
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CovinaUnited StatesUnknown status
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Creve CoeurUnited StatesUnknown status
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DallasUnited StatesUnknown status
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DaphneUnited StatesUnknown status
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Daytona BeachUnited StatesUnknown status
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DenverUnited StatesUnknown status
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DouglasvilleUnited StatesUnknown status
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DurhamUnited StatesUnknown status
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East ProvidenceUnited StatesUnknown status
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El DoradoUnited StatesUnknown status
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ElkhartUnited StatesUnknown status
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El PasoUnited StatesUnknown status
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EncinitasUnited StatesUnknown status
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EvansvilleUnited StatesUnknown status
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FlintUnited StatesUnknown status
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FoleyUnited StatesUnknown status
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Fort MyersUnited StatesUnknown status
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GainesvilleUnited StatesUnknown status
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Garden GroveUnited StatesUnknown status
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GermantownUnited StatesUnknown status
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GilbertUnited StatesUnknown status
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GreensboroUnited StatesUnknown status
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GreenvilleUnited StatesUnknown status
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HartfordUnited StatesUnknown status
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HollywoodUnited StatesUnknown status
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HoustonUnited StatesUnknown status
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Huntington BeachUnited StatesUnknown status
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HuntsvilleUnited StatesUnknown status
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JacksonvilleUnited StatesUnknown status
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Jensen BeachUnited StatesUnknown status
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KalispellUnited StatesUnknown status
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KnoxvilleUnited StatesUnknown status
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Lake CityUnited StatesUnknown status
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LanghorneUnited StatesUnknown status
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Las VegasUnited StatesUnknown status
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LincolnUnited StatesUnknown status
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Los AngelesUnited StatesUnknown status
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MagnoliaUnited StatesUnknown status
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ManassasUnited StatesUnknown status
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MarionUnited StatesUnknown status
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MemphisUnited StatesUnknown status
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MiamiUnited StatesUnknown status
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MiddleburyUnited StatesUnknown status
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MinneapolisUnited StatesUnknown status
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MiramarUnited StatesUnknown status
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MonroeUnited StatesUnknown status
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MontgomeryUnited StatesUnknown status
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Myrtle BeachUnited StatesUnknown status
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New OrleansUnited StatesUnknown status
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NewportUnited StatesUnknown status
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NewtonUnited StatesUnknown status
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New YorkUnited StatesUnknown status
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NorfolkUnited StatesUnknown status
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NormanUnited StatesUnknown status
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NorthridgeUnited StatesUnknown status
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Oklahoma CityUnited StatesUnknown status
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OmahaUnited StatesUnknown status
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OrlandoUnited StatesUnknown status
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OwensboroUnited StatesUnknown status
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PasadenaUnited StatesUnknown status
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PhiladelphiaUnited StatesUnknown status
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PhoenixUnited StatesUnknown status
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PortsmouthUnited StatesUnknown status
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RaleighUnited StatesUnknown status
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Rapid CityUnited StatesUnknown status
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RichfieldUnited StatesUnknown status
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RichmondUnited StatesUnknown status
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San AntonioUnited StatesUnknown status
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San DiegoUnited StatesUnknown status
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San DimasUnited StatesUnknown status
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SavannahUnited StatesUnknown status
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ShelbyUnited StatesUnknown status
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ShenandoahUnited StatesUnknown status
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ShermanUnited StatesUnknown status
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Simi ValleyUnited StatesUnknown status
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StephenvilleUnited StatesUnknown status
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Sun CityUnited StatesUnknown status
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TempeUnited StatesUnknown status
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The VillagesUnited StatesUnknown status
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ThomasvilleUnited StatesUnknown status
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TomballUnited StatesUnknown status
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TucsonUnited StatesUnknown status
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TupeloUnited StatesUnknown status
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VacavilleUnited StatesUnknown status
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Van NuysUnited StatesUnknown status
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Washington D.C.United StatesUnknown status
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WaterburyUnited StatesUnknown status
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West AllisUnited StatesUnknown status
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West HillsUnited StatesUnknown status
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West SpringfieldUnited StatesUnknown status
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WichitaUnited StatesUnknown status
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WilmingtonUnited StatesUnknown status
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Winston-SalemUnited StatesUnknown status
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Winter HavenUnited StatesUnknown status
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YpsilantiUnited StatesUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.