NCT06273072RecruitingPhase 2
Metformin IN Asthma for Overweight and Obese Individuals (MINA)
Source: ClinicalTrials.gov · Last updated 16 Oct 2026
Brief summary (registry, in English)
This is a randomized clinical trial of metformin among overweight or obese adults with not well-controlled asthma despite maintenance inhaler therapy.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 100 (estimated)
- First submitted
- 15 Feb 2024
- Start date
- 9 Dec 2024
- Primary completion date
- 31 Dec 2026
- Lead sponsor
- Johns Hopkins University
- NCT number
- NCT06273072
What you commit to
- Study type: Interventional · Phase 2
- Planned participants: 100
- From 9 Dec 2024 to the primary completion date, 31 Dec 2026
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Taking Glucagon Like Peptide 1(GLP-1) medications for weight loss
Other illness
- Major cardiovascular disease: heart failure, heart attack or stroke within the last 6 months
- Other chronic lung disease, inclusive of chronic obstructive pulmonary disease, bronchiectasis, interstitial lung disease, pulmonary fibrosis
- Chronic kidney disease: estimated glomerular filtration rate ≤60 mL/min/1.73 m2
Lab values
- Liver disease: elevation in aspartate aminotransferase (AST) or alanine aminotransferase (ALT) \> 2x the upper limit of normal or prior diagnosis of liver disease
- Anemia: hemoglobin \< 13 g/dl in males and hemoglobin \< 11 g/dl in females
- Diabetes (Hemoglobin A1C ≥ 6.5% or taking metformin or other medications used to treat diabetes)
Other
- Currently pregnant, expect to become pregnant in the next 6 months or are currently breastfeeding
- Active smoking or former smoker with ≥20 pack-year smoking history
- Heavy alcohol use: in a typical week, 8 or more drinks for a woman or 15 or more drinks for a man
- Participation in any other clinical trial (observational studies are permitted)
Who the study is looking for
- Physician-diagnosed asthma on maintenance therapy
- Not well-controlled asthma (ACT score \<20, or at least one asthma exacerbation requiring corticosteroids in the prior 12 months)
- Overweight or obesity: Body mass index ≥25kg/m2
- Adult: Age ≥18
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Johns Hopkins University Coordinator of this site? Confirm its status | Baltimore | United States | Recruiting |
| Baylor College of Medicine Coordinator of this site? Confirm its status | Houston | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.