NCT06274112Recruiting
Using TMS to Understand Neural Processes of Social Motivation
Personalized Neuromodulation Targeting Dysregulated Motivational Responses Underlying Social Avoidance Behavior
Source: ClinicalTrials.gov · Last updated 3 Mar 2026
Brief summary (registry, in English)
The purpose of this study is to use transcranial magnetic stimulation (TMS) to better understand the neural circuits associated with social motivation. Participant includes four study visits each that range from 1.5 - 3.0 hours in duration over approximately a one month period. The first study visit involves answering survey questions, a clinical interview, and computer tasks. The second study visit involves a magnetic resonance imaging (MRI) scan, computer tasks, and a brief TMS protocol. The second and third study visits involve a full session of TMS followed by an MRI scan and computer tasks. Adults in the Auburn/Opelika area and surrounding areas who avoid social situations, experience symptoms of depression or social anxiety, and are between 25 years old and 50 years old are eligible to participate.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 40 (estimated)
- First submitted
- 8 Feb 2024
- Start date
- 30 Sept 2025
- Primary completion date
- 31 Jul 2029
- Lead sponsor
- Auburn University
- Diseases
- Depression
- NCT number
- NCT06274112
What you commit to
- Study type: Interventional
- Planned participants: 40
- From 30 Sept 2025 to the primary completion date, 31 Jul 2029
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Unstable psychotropic medication regimen (i.e., changes in psychotropic medication or dosage in past 3 months).
- Ferromagnetic implants or ferrmagnetic objects within body (e.g., pacemaker).
Other illness
- Current or lifetime diagnosis of Bipolar Disorder.
- A diagnosis of substance use disorder within past 12 months.
- A diagnosis of psychotic-spectrum disorder such as Schizophrenia.
- Medical illness or medical treatment that would preclude or inhibit study participation.
- Neurological disorder associated with brain damage.
- History of seizures or head trauma with loss of consciousness \> 5 minutes.
- Family history of epilepsy or personal epilepsy/seizures
Other
- Pregnancy or probable pregnancy.
Who the study is looking for
- A diagnosis of Major Depressive Disorder OR a diagnosis of Social Anxiety Disorder (assessed/confirmed at screening visit).
- Scoring above clinical threshold on a measure of social avoidant behavior (assessed/confirmed at phone screen).
Age in the registry: 25 years to 50 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Auburn University Coordinator of this site? Confirm its status | Auburn | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.