NCT06287814Recruiting
French Assessment of MRD by Liquid Biopsies in Stage III CRC Patients (FRENCH.MRD.CRC)
French Assessment of Minimal Residual Disease by Liquid Biopsies in Stage III Colorectal Patients
Source: ClinicalTrials.gov · Last updated 18 Aug 2026
Brief summary (registry, in English)
Improving personalized cancer treatments and finding the best strategies to treat each patient relies on using new diagnostic technologies. Currently, for colorectal cancer, the methods used to decide who gets additional post-surgery treatment are suboptimal. Some patients get too much treatment, while others do not get enough. There is a new way to explore if there is any cancer left in a patient's body using circulating tumor DNA (ctDNA) detected in blood samples. This can help decide who needs more treatment after surgery. Even though many tests have been developed, it has yet to be determined which test performs best at relevant time points. The GUIDE.MRD consortium is a group of experts, including scientists, technology, and pharmaceutical companies. The consortium is working on creating a reliable standard for the ctDNA tests, validating their clinical utility, and collecting data to help decide on the best treatment for each patient. FRENCH-MRD-CRC is the French study of the european GUIDE.MRD project.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 70 (estimated)
- First submitted
- 8 Feb 2024
- Start date
- 11 Apr 2024
- Primary completion date
- 11 Apr 2027
- Lead sponsor
- University Hospital, Montpellier
- Diseases
- Colorectal cancer
- NCT number
- NCT06287814
What you commit to
- Study type: Observational
- Planned participants: 70
- From 11 Apr 2024 to the primary completion date, 11 Apr 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Participation in FRENCH.MRD.CRC part 1 - SURGERY
- Has received curative-intent resection and is a candidate for adjuvant chemotherapy (3- or 6-months regime) Exclusion criteria
- Not treated with adjuvant chemotherapy despite indication (incomplete treatment not included)
- Treated with neoadjuvant chemo-radiation therapy
Other illness
- Hereditary colorectal cancer linked to familial colonic polyposis or Lynch syndrome.
- Malignant colorectal polyps diagnosed after polypectomy.
- Colorectal cancer, UICC stage III
- Inflammatory bowel disease (Crohn's disease or ulcerative colitis) related colon cancer
- Synchronous colorectal and non-colorectal cancer diagnosed per operative (except skin cancer other than melanoma)
- Other cancers (excluding colorectal cancer or skin cancer other than melanoma) within 3 years from eligibility screening
Age
- Pregnant or nursing woman, or in childbearing age and not willing to use contraception
Other
- Verified distant metastases.
- Patients who are unlikely to comply with the protocol (e.g. uncooperative attitude), inability to return for subsequent visits) and/or otherwise considered by the Investigator to be unlikely to complete the study.
- Protected and vulnerable adult
- Not covered by Health insurance
- Patient unable to understand and sign written informed consent.
- FRENCH.MRD.CRC PART II Inclusion criteria
- Patients who are unlikely to comply with the protocol (e.g. uncooperative attitude), inability to return for subsequent visits) and/or otherwise considered by the Investigator to be unlikely to complete the study
Criteria the registry did not label
- FRENCH.MRD.CRC PART I Inclusion criteria
- Colon or rectal cancer, clinical tumor stage I-III.
- Patient 18 years or older.
- Scheduled for curative intent resection surgery (including "compromised" curative resections).
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| CHU de Montpellier Coordinator of this site? Confirm its status | Montpellier | France | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.