NCT06289257Completed
Analysis of Vitamin D and VDR Expression in Endometriosis: A Case-Control Study
Analysis of Vitamin D and VDR Expression in Women With Advanced Endometriosis: A Case-Control Study in Thailand
Source: ClinicalTrials.gov · Last updated 4 Jul 2025
Brief summary (registry, in English)
The goal of this cross-sectional prospective matching study is to evaluate whether serum vitamin D levels and vitamin D receptor (VDR) expression are associated with the presence and severity of endometriosis in women of reproductive age. The main questions it aims to answer are: * Is there a difference in serum 25-hydroxyvitamin D \[25(OH)D\] levels between women with endometriosis and healthy controls? * Is there a correlation between serum vitamin D levels and VDR expression in endometriotic tissues? * Is there an association between vitamin D status and the severity of endometriosis based on the revised American Society for Reproductive Medicine (rASRM) staging? Researchers will compare participants with endometriosis to matched healthy controls (1:2 ratio). Participants will: * Provide blood samples for serum 25(OH)D measurement. * Undergo surgical tissue sampling (for the endometriosis group) to assess VDR expression using immunohistochemistry staining. * Complete structured questionnaires regarding sun exposure, lifestyle, and clinical characteristics.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 108 (actual)
- First submitted
- 20 Feb 2024
- Start date
- 6 May 2024
- Primary completion date
- 23 Dec 2024
- Lead sponsor
- Khon Kaen University
- Diseases
- Endometriosis
- NCT number
- NCT06289257
What you commit to
- Study type: Observational
- Participants enrolled: 108
- From 6 May 2024 to the primary completion date, 23 Dec 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Received vitamin D supplements within the past 3 months prior to volunteering.
- Previously treated for autoimmune diseases.
- History of bone disorders or receiving medications affecting bones.
Other illness
- History of chronic infectious diseases.
- History of polycystic ovarian.
Other
- Irregular menstrual cycles or absence of menstruation for more than 3 months up to 1 year.
Who the study is looking for
- Women diagnosed with ectopic endometriotic tissue:
- Have a scheduled surgery appointment at Sri Nakarin Hospital.
- Are aged 18 years or older.
- Women undergoing examination at the outpatient department of Sri Nakarin Hospital.
- No history of gynecological diseases or previous treatment for gynecological conditions associated with lower abdominal pain, infections, or abdominal masses at present.
- Have undergone a gynecological examination within the past year, or if examined during the current visit, the results were normal.
- Have undergone an ultrasound examination within the past year, or if examined during the current visit, the ultrasound results were normal.
Age in the registry: 18 years to - · Sex: Female · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Department of Obstetrics and Gynecology, Faculty of Medicine, Khonkaen University Coordinator of this site? Confirm its status | Khon Kaen | Thailand | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.