NCT06290245Completed
PEP Buddy Impact on Breathing, Exercise, and Sleep Quality in COPD Patients
Effect of PEP Buddy During Aerobic Training on Breathing, Exercise, and Sleep Quality in COPD Patients
Source: ClinicalTrials.gov · Last updated 22 Aug 2025
Brief summary (registry, in English)
Exercise intolerance and sleeping problems are among the most common symptoms experienced by patients with chronic obstructive pulmonary disease (COPD), which is associated with lung dynamic hyperinflation (DH). There was evidence that positive expiratory pressure (PEP), which less costly devices could offer, could reduce DH. A positive expiratory pressure device improved COPD-related symptoms in more than 70% of patients with COPD. PEP buddy is an adjunct to current COPD therapies, such as inhalers and pulmonary rehabilitation. It provides a tool for self-management and breathing re-training, reducing dyspnea and improving quality of life.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 60 (actual)
- First submitted
- 21 Feb 2024
- Start date
- 23 Mar 2024
- Primary completion date
- 25 May 2025
- Lead sponsor
- Cairo University
- Diseases
- COPD
- NCT number
- NCT06290245
What you commit to
- Study type: Interventional
- Participants enrolled: 60
- From 23 Mar 2024 to the primary completion date, 25 May 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- • Very severe COPD - Lung cancer
- Lung resection - Lung fibrosis
- Heart failure - Cognitive disorders that affect the device application
- Musculoskeletal or neurological disorders that interfere with an exercise program
- requiring invasive or non-invasive positive pressure ventilation
- inability to speak in complete sentences due to breathlessness
- suspected elevated intracranial pressure - hemodynamic instability
- recent facial, oral, or skull surgery
- active hemoptysis (more than two tablespoons of frank blood per day)
- pneumothorax - failure to comply with the research protocol.
- uncontrolled hypertension, or other concomitant respiratory diseases
- participate in any research or pulmonary rehabilitation program during the period of this study.
- imaging changes of lung disease such as occupancy, exudation, and interstitial changes on CT scan
Who the study is looking for
- • All gender COPD patients
- Age will be 55-65 years.
- Moderate to severe COPD patients
- emphysema on CT scan (HU ≥ - 900)
- Their FEV1 will be less than 80% predicted
- Class II obesity (BMI of 35 to \< 40)
- Medically stable
- greater than 10 pack-year smoking history
Age in the registry: 55 years to 65 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Faculty of Physical Therapy Coordinator of this site? Confirm its status | Giza | Egypt | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.