TAS-102 Combined With Bevacizumab for Second-line Maintenance Treatment of Advanced Colorectal Cancer

Prior treatment

• Any CTCAE grade 1 or above toxicity caused by previous treatment that has not yet subsided (excluding alopecia, skin pigmentation, and chemotherapy-induced neurotoxicity);
• Poorly controlled hypertension (systolic blood pressure \>150 mmHg and/or diastolic blood pressure \>100 mmHg) with a previous history of hypertensive crisis or hypertensive encephalopathy;
• Known inherited or acquired bleeding (e.g., coagulopathy) or thrombophilia, as in patients with hemophilia; Current or recent (within 10 days before initiation of study treatment) use of a full-dose oral or injectable anticoagulant or thrombolytic agent for therapeutic purposes (prophylactic use of low-dose aspirin and low-molecular-weight heparin is allowed);
• Thrombotic or embolic events, such as cerebrovascular accident (including transient ischemic attack, cerebral hemorrhage, cerebral infarction), pulmonary embolism, etc., occurred within 6 months before the initiation of study treatment;
• Has undergone major surgical treatment (excluding diagnosis) within 4 weeks before the start of the study or is expected to undergo major surgical treatment during the study period;
• Active infection or fever of unknown origin \> 38.5 ° C within 2 weeks before the first dose (tumor-related fever, as judged by the investigator, was eligible);
• Prior treatment with TAS-102;
• Abdominal fistula, gastrointestinal perforation, or abdominal abscess within 6 months before study treatment;

Other illness

• Known history or evidence of interstitial lung disease or active noninfectious pneumonia;
• Have bleeding tendency and high risk of bleeding;
• Inability to swallow tablets, malabsorption syndrome or any condition affecting gastrointestinal absorption;
• Patients with congenital or acquired immune deficiency (such as HIV infection);
• Active hepatitis (hepatitis B reference: HBsAg positive and HBV DNA≥2000 IU/ml; Hepatitis C reference: HCV antibody positive and HCV virus copy number \> upper limit of normal);
• Acute or subacute intestinal obstruction, or chronic inflammatory bowel disease;
• Have poorly controlled cardiac clinical symptoms or disease；
• Patients with other malignant tumors within 5 years before enrollment, except basal cell carcinoma of the skin or carcinoma in situ of the cervix;

Other

• Severe, unhealed or dehiscence wounds and active ulcers or untreated fractures;
• Known brain and/or leptomeningeal metastases. All subjects should receive brain CT/MRI to exclude brain metastases;
• Pregnant or lactating women;
• Patients with genotype MSI-H;
• The investigator assessed that it is not appropriate to participate in the study.

• Subjects voluntarily participate in this study, sign the informed consent form, and have good compliance;
• Age ≥18 years old;
• Unresectable colorectal adenocarcinoma confirmed by histopathology or cytology;
• After receiving 12 weeks of standard chemotherapy (FOLFOX, FOLFIRI, or CAPEOX) combined with bevacizumab second-line induction therapy, the patients are confirmed as CR, PR, or SD according to RECIST 1.1 criteria;
• The interval between the last second-line induction therapy and randomization is not more than 6 weeks;
• At least one measurable lesion according to RECIST 1.1 criteria;
• ECOG Performance Status 0-2;
• Estimated life expectancy ≥12 weeks;
• Adequate major organ function (no medication for blood component, cell growth factor correction therapy is allowed within 14 days before randomization);
• Women of child-bearing potential must agree to abstain from sex (heterosexual intercourse) or use a reliable, effective method of contraception from the time they provide informed consent until at least 90 days after the last dose of study drug is administered. Serum or urine HCG test must be negative. And must be non-lactating;
• Male participants whose partner is a woman of child-bearing potential must agree to abstain from sex or use a reliable,effective method of contraception from the time they sign an informed consent form until at least 90 days after the last dose of study drug is administered. Male subjects also have to agree not to donate sperm during the same period.