NCT06293703Recruiting
Effect of Limb Length Ratio on Roux-en-Y Gastric Bypass Outcomes (CLIMB II Study)
Source: ClinicalTrials.gov · Last updated 20 Mar 2026
Brief summary (registry, in English)
The investigators propose a randomized controlled trial comparing BP and roux limb lengths measuring 30 and 15% respectively of patient's total small bowel length versus current standard practice using fixed lengths. The findings would provide further insight into feasibility of standardizing RYGB limb lengths and optimizing resultant weight loss and metabolic effects. The investigators hypothesize RYGB with ratio-adjusted limb lengths (aRYGB) will result in higher total weight loss and resolution of metabolic syndrome comorbidities, including diabetes, hyperlipidemia, and hypertension compared to standard fixed-length RYGB (sRYGB). The study will also utilize the Short Form Rand 36-Item Health Survey (SF36) to determine differences in postoperative quality of life metrics.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 262 (estimated)
- First submitted
- 19 Feb 2024
- Start date
- 12 Jan 2024
- Primary completion date
- 11 Dec 2030
- Lead sponsor
- Salvador Navarrete
- Diseases
- Obesity
- NCT number
- NCT06293703
What you commit to
- Study type: Interventional
- Planned participants: 262
- From 12 Jan 2024 to the primary completion date, 11 Dec 2030
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- patients with history of previous bariatric surgery procedures
- previous gastric or small bowel resection
Other illness
- active cancer
Other
- individuals unable to understand and sign a written consent form
- presence of a severe and evolutive life threatening pathology unrelated to obesity
- pregnancy or desired to be pregnant during the study
- mentally unbalanced patients under supervision or guardianship, patient unable to give consent
Who the study is looking for
- morbidly obese patients (defined by BMI between 40 and 60).
- Patient who understands and accepts the need for a long-term follow-up.
- Patient who agrees to be included in the study
Age in the registry: 18 years to 70 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Cleveland Clinic Coordinator of this site? Confirm its status | Cleveland | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.