NCT06295692Active, not recruitingPhase 3
A Study of JNJ-77242113 for the Treatment of Participants With Generalized Pustular Psoriasis or Erythrodermic Psoriasis
77242113PSO3005: 77242113PSO3005 Ph III Trial Local Study (N=20) {EP/GPP}
Source: ClinicalTrials.gov · Last updated 28 Sept 2026
Brief summary (registry, in English)
The purpose of this study is to evaluate how effective JNJ-77242113 is in participants with generalized pustular psoriasis (GPP) or erythrodermic psoriasis (EP).
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 19 (actual)
- First submitted
- 29 Feb 2024
- Start date
- 9 Feb 2024
- Primary completion date
- 14 Jan 2025
- Lead sponsor
- Janssen Pharmaceutical K.K.
- Diseases
- Psoriasis
- NCT number
- NCT06295692
What you commit to
- Study type: Interventional · Phase 3
- Participants enrolled: 19
- From 9 Feb 2024 to the primary completion date, 14 Jan 2025
- 12 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- The study participant has a differential diagnosis of the erythroderma (for example, erythroderma caused by lymphoma or drug eruption) other than EP
- The study participant who doesn't meet the criteria of prior/current concomitant therapy and/or history/conditions of infections
Other illness
- The study participant has a history of or current diagnosis or signs or symptoms of severe, progressive, or uncontrolled liver, renal; cardiac, vascular, pulmonary, gastrointestinal, endocrine, neurologic, hematologic, rheumatologic, psychiatric, or metabolic disturbances
- The study participant has a history of amyloidosis
- Known allergies, hypersensitivity, or intolerance to JNJ-77242113 or its excipients
Other
- The study participant has a total score of JDA severity index for GPP \>=14 at baseline if participants have a diagnosis of GPP
Who the study is looking for
- The study participant has a diagnosis of generalized pustular psoriasis (GPP) or erythrodermic psoriasis (EP) at screening. For GPP, a diagnosis must be classified based on the criteria for diagnosis of GPP by the Japanese Dermatological Association (JDA); for EP, has a history of plaque-type psoriasis. In addition, has an involved body surface area (BSA) of lesion greater than or equal to (\>=) 80 percent (%) at baseline
- Candidate for phototherapy or systemic treatment for psoriasis (either naive or history of previous treatment)
- A female participant of childbearing potential must have a negative highly sensitive serum pregnancy test (beta-human chorionic gonadotropin \[beta-hCG\]) at screening and have a negative urine pregnancy test at Week 0 prior to administration of study intervention
- A male participant must agree not to plan to father a child while enrolled in this study or within 90 days after the last dose of study intervention
- A male participant must agree not to donate sperm for the purpose of reproduction during the study and for a minimum of 90 days after receiving the last dose of study intervention
Age in the registry: 12 years to - · Sex: All · Does not accept healthy volunteers
Sites (12)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| JR Sapporo Hospital Coordinator of this site? Confirm its status | Hokkaido | Japan | Unknown status |
| Ichinomiya Municipal Hospital Coordinator of this site? Confirm its status | Ichinomiya | Japan | Unknown status |
| Hospital of the University of Occupational and Environmental Health Coordinator of this site? Confirm its status | Kitakyushu-shi | Japan | Unknown status |
| Kumamoto University Hospital Coordinator of this site? Confirm its status | Kumamoto | Japan | Unknown status |
| Nagoya City University Hospital Coordinator of this site? Confirm its status | Nagoya | Japan | Unknown status |
| Public Interest Incorporated Foundation Nipoon Life Saiseikai Nippon Life Hospital Coordinator of this site? Confirm its status | Osaka | Japan | Unknown status |
| Tohoku University Hospital Coordinator of this site? Confirm its status | Sendai | Japan | Unknown status |
| Dokkyo Medical University Hospital Coordinator of this site? Confirm its status | Shimotsuga-gun | Japan | Unknown status |
| Tokyo Medical University Hospital Coordinator of this site? Confirm its status | Shinjuku | Japan | Unknown status |
| Teikyo University Hospital Coordinator of this site? Confirm its status | tabashi City | Japan | Unknown status |
| Fujita Health University Hospital Coordinator of this site? Confirm its status | Toyoake | Japan | Unknown status |
| Mie University Hospital Coordinator of this site? Confirm its status | Tsu | Japan | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.