NCT06297928Completed
Metabolomics and Bariatric Surgery in Patients With Metabolically Unhealthy Obesity
Metabolomics and Bariatric Surgery in Patients With Metabolically Unhealthy Obesity: Advancing Precision Medicine for the Treatment of Obesity
Source: ClinicalTrials.gov · Last updated 3 Jun 2025
Brief summary (registry, in English)
The goal of this observational study is to investigate metabolic changes in individuals undergoing bariatric surgery, specifically focusing on those with obesity and varying metabolic health statuses. The main questions it aims to answer are: * Can metabolic markers predict the transition from metabolically unhealthy obesity to metabolically healthy obesity after bariatric surgery? * How do metabolic profiles change in individuals with metabolically healthy obesity after bariatric surgery? * What are the metabolic differences between individuals with metabolically healthy and unhealthy obesity before and after bariatric surgery? Participants will undergo routine evaluations and blood tests before and after bariatric surgery. These tests will include assessments of metabolic health markers and sampling of blood plasma for metabolomic analysis. The study will study changes in metabolic profiles between individuals who transition to metabolically healthy obesity and those who remain metabolically unhealthy after surgery. In January 2025, a new definition of clinical obesity was proposed by the Lancet Commission, focusing on organ/system dysfunction induced by excess adiposity. In response, this study has expanded its objectives to assess the prevalence, predictors, and metabolomic correlates of clinical obesity and its remission after bariatric surgery.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 145 (actual)
- First submitted
- 22 Feb 2024
- Start date
- Jan 2024
- Primary completion date
- Apr 2025
- Lead sponsor
- Parc de Salut Mar
- Diseases
- Obesity
- NCT number
- NCT06297928
What you commit to
- Study type: Observational
- Participants enrolled: 145
- From Jan 2024 to the primary completion date, Apr 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- History of previous bariatric surgery.
Other illness
- Presence of severe psychiatric disorders, severe eating disorders, alcohol or drug abuse.
- Contraindications for major abdominal surgery, active gastric ulcer, severe liver disease.
- Pregnancy or lactation.
Who the study is looking for
- Patients undergoing bariatric surgery at the Hospital del Mar in Barcelona. Criteria for bariatric surgery are:
- Ages between 18 and 60 years.
- Body Mass Index (BMI) equal to or greater than 40, or equal to or greater than 35 kg/m2 with at least one obesity-related comorbidity (type 2 diabetes mellitus, hypertension, dyslipidemia, obstructive sleep apnea syndrome).
- Previous failure with conventional treatment involving diet and exercise.
Age in the registry: 18 years to 60 years · Sex: All
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hospital del Mar Coordinator of this site? Confirm its status | Barcelona | Spain | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.