NCT06302660Active, not recruiting
Profiling Microbiome Associated Metabolic Pathways in Oesophageal Cancer Survivors
Source: ClinicalTrials.gov · Last updated 27 Jan 2025
Brief summary (registry, in English)
The goal of this observational study is to learn about long term symptoms in oesophageal cancer survivors. The main question it aims to answer is are: * Study the changes in gut bacteria by examining saliva, stool and blood. * Investigate the products of bacteria in breath to develop a non-invasive breath test to detect the changes in gut bacteria. * Develop new strategies to treat this change and trial new treatments to improve quality- of-life in oesophageal cancer survivors. Participants will attend an outpatient clinic, fasted for at least 4 hours for collection of breath, saliva, blood, urine, stool and complete validated healthy-related quality-of-life questionnaires. Researchers will compare symptomatic and asymptomatic participants to detect the changes stated above.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 100 (actual)
- First submitted
- 4 Mar 2024
- Start date
- 9 Mar 2022
- Primary completion date
- 1 Oct 2025
- Lead sponsor
- Imperial College London
- Diseases
- Gastric and esophageal cancer
- NCT number
- NCT06302660
What you commit to
- Study type: Observational
- Participants enrolled: 100
- From 9 Mar 2022 to the primary completion date, 1 Oct 2025
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients who have received antibiotic therapy within the last 4 weeks
Other illness
- Patients with evidence of disease recurrence
Other
- Patients with Siewert III gastro-oesophageal junctional tumours
- Patients who are unable or unwilling to provide informed written consent
Who the study is looking for
- Male and female patients aged 18-90 years
- Patients who underwent oesophagectomy for oesophageal adenocarcinoma with curative intent
- Disease free patients (CT with no evidence of recurrence within last 6 months or more than 5 years post oesophageal resection)
- Patients more than 1 year post oesophageal resection
Age in the registry: 18 years to 90 years · Sex: All · Does not accept healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| West Hertfordshire NHS Teaching Hospitals Coordinator of this site? Confirm its status | London | United Kingdom | Unknown status |
| Imperial College Healthcare NHS Trust Coordinator of this site? Confirm its status | London | United Kingdom | Unknown status |
| Barking, Havering and Redbridge University Hospitals NHS Trust Coordinator of this site? Confirm its status | London | United Kingdom | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.